Abstract
The first studies of cross idiotypes among rheumatoid factors involved monoclonal IgM anti globulins (mRF) obtained mainly from patients with mixed cryoglobulinemia (Kunkel, 1973). Two distinct idiotype groups were described, a major group WA comprising approximately 60% of those proteins and a minor group PO comprising 20%; 20% were uncharacterized. More recently a third rheumatoid factor cross idiotype has been defined, the Bla group, that is distinct from the PO and WA groups (Agnello, 1980). The rheumatoid factors (RF) in this group are unique in that in addition to reactivity with an antigen on IgG they cross react with an antigen on DNA-nucleoprotein.
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References
Agnello V, Arbetter A, Ibanez de Kasep G, Powell R, Tan EM and Joslin F: J Exp Med 151: 1514–1527, 1980.
Agnello V, Ibanez de Kasep G and Mitamura T: In: Y Shiokawa, T Abe and Y Yamauchi, New Horizons in Rheumatoid Arthritis, Amsterdam: Excerpta Medicus, 1980b, pp 71–75.
Aitcheson C, Peebles C, Joslin F and Tan EM: Arth Rheum 23: 528–538, 1980.
Bonagura VR, Kunkel HG and Pernis B: J Clin Invest 69: 1356–1365, 1982.
Carson DA, Pasquali J, Tsoukas CD, Fong S, Slovin SF, Lawrence SK, Sloughter L and Vaughan JH: Springer Semin Immunopathol 4: 161–179, 1981.
Forre O, Dublong JH, Michaelsen TE and Natvig JB: Scand J Immunol 9: 281–289, 1979.
Gabriel JR, A and Agnello V: J Clin Invest 59: 990–1001, 1977.
Johnson PM: Scan J Immunol 9: 461–466, 1979.
Kunkel HG, Agnello V, Joslin FG, Winchester J and Capra JD: J Exp Med 137: 331–342, 1973.
Powell R and Agnello V: Clin Immunol Immunopath 29: 146–151, 1983.
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Agnello, V. (1986). Subsets of rheumatoid factors determined by cross idiotypes. In: Ponticelli, C., Minetti, L., D’Amico, G. (eds) Antiglobulins, cryoglobulins and glomerulonephritis. Developments in Nephrology, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4289-9_2
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DOI: https://doi.org/10.1007/978-94-009-4289-9_2
Publisher Name: Springer, Dordrecht
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