Abstract
Chicken anaemia agent (CAA) has been studied in vivo and in vitro. Avian infectious anaemia (AIA) was considerably aggravated in chicks dually infected at day-old with CAA and virulent Marek’s disease virus (MDV), infectious bursal disease virus (IBDV), or reticuloendotheliosis virus (REV). CAA-induced gross and histological lesions were characterized by panmyelophthisis and generalized lymphoid atrophy, and resembled those of the syndrome of anaemia, panmyelopathy and haemorrhagic diathesis occurring in the field. Circumstantial evidence suggested that CAA is also causing a severe immunodepression in neonatally infected chicks.
CAA replicates in cultured cells of the MDCC-MSB1 lymphoblastoid cell line. Cytopathic effects occurred by 30 hours postinoculation (p.i.) and were characterized by enlargement and subsequent destruction of cells. Infected MSB1 cells have been found to be suitable at 34 to 44 hours p.i. for indirect immunofluorescence tests to detect intranuclear CAA antigens or anti-CAA antibody, respectively.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bülow, V.v., Fuchs, B., Vielitz, E. and Landgraf, H. 1983. Frühsterblich- keitssyndrom bei Küken nach Doppelinfektion mit dem Virus der Mareksehen Krankheit (MDV) und einem Anämie-Erreger (CAA). Zbl. Vet. Med. B, 30, 742–750.
Bülow, V.v., Fuchs, B. and Bertram, M. 1985a. Untersuchungen über den Erreger der infektiösen Anämie bei Hühnerküken (CAA) in vitro: Vermehrung, Titration, Serumneutralisationstest und indirekter Immunfluoreszenztest. Zbl. Vet. Med. B (in press).
Bülow, V.v., Rudolph, R. and Fuchs, B. 1985b. Erhöhte Pathogenität des Er-regers einer infektiösen Anämie bei Hühnerküken (CAA) bei simultaner Infektion mit dem Virus der Marekschen Krankheit (MDV), Bursitisvirus (IBDV) oder Reticuloendotheliosevirus (REV). Zbl. Vet. Med. B (in press).
Dorn, P., Weikel, J. and Wessling, E. 1981. Anämie, Rückbildung der lympha-tischen Organe und Dermatitis - Beobachtungen zu einem neuen Krank-heitsbild in der Geflügelmast.-Dtsch. Tierärztl. Wschr., 88, 313–315.
Engström, B.E. and Luthman, M. 1984. Blue wing disease of chickens: Signs, pathology and natural transmission. Avian Pathol., 13, 1–12.
Fadly, A.M. and Winterfield, R.W. 1973. Isolation and some characteristics of an agent associated with inclusion body hepatitis, hemorrhages, and aplastic anemia in chickens. Avian Dis., 17, 182–193.
Hoffmann, R. and Dorn, P. 1978. Histological development of lesions in the bursa of Fabricius of chickens with inclusion body hepatitis. Avian Dis., 22, 266–272.
Hoffmann, R., Dorn, P. and Dangschat, H. 1973. Ein neues durch Panmyelopathie, Anämie und hämorrhagische Diathese gekennzeichnetes Syndrom beim Huhn. Zbl. Vet. Med. B, 20, 741–746.
Hoffmann, R., Wessling, E., Dorn, P. and Dangschat, H. 1975. Lesions in chickens with spontaneous or experimental infectious hepato-myelopoietic disease. Avian Dis., 19 224–23.
Köhler, H. and Hromatka-Vasicek, L. 1974. Einschlußkörper-Hepatitis bei Broilern in Österreich. Wien. Tierärztl. Mschr., 61, 90–95.
Randall, C.J., Miller, W.G., Wallis, A.S. and Kirkpatrick, K.S. 1984. Multiple infections in young broilers. Vet. Ree., 114, 270–271.
Rosenberger, J.K., Klopp, S., Eckroade, R.J. and Krauss, W.C. 1975. The role of infectious bursal agent and several avian adenoviruses in the hemorrhagic-aplastic-anemia syndrome and gangrenous dermatitis. Avian Dis., 19, 717–729.
Taniguchi, T., Yuasa, N., Maeda, M. and Horiuchi, T. 1983. Chronological observations on hemato-pathologieal changes in chicks inoculated with chicken anemia agent. Natl. Inst. Anim. Health Quart., 23, 1–12.
Yuasa, N. 1983. Propagation and infectivity titration of the Gifu-1 strain of chicken anemia agent in a cell line (MDCC-MSB1) derived from Marek’s disease lymphoma. Natl. Inst. Anim. Health Quart., 23, 13–30.
Yuasa, N. and Yoshida, I. 1983. Experimental egg transmission of chicken anemia agent. Natl. Inst. Anim. Health Quart., 23, 99–100.
Yuasa, N., Taniguchi, T. and Yoshida, I. 1979. Isolation and some characte-ristics of an agent inducing anemia in chicks. Avian Dis., 23, 366–385.
Yuasa, N., Noguchi, T., Furata, K. and Yoshida, I. 1980a. Maternal antibody and its effect on the susceptibility of chicks to chicken anemia agent. Avian Dis., 24, 197–201.
Yuasa, N., Taniguchi, T., Noguchi, T. and Yoshida, I. 1980b. Effect of in-fectious bursal disease virus infection of chickens on anemia by chicken anemia agent. Avian Dis., 24, 202–209.
Yuasa, N., Taniguchi, T., Imada, T. and Hihara, H. 1983a. Distribution of chicken anemia agent (CAA) and detection of neutralizing antibody in chicks experimentally inoculated with CAA. Natl. Inst. Anim. Health Quart., 23, 78–81.
Yuasa, N., Taniguchi, T., Goda, M., Shibatani, M., Imada, T. and Hihara, H. 1983b. Isolation of chicken anemia agent with MDCC-MSB1 cells from chickens in the field. Natl. inst. Anim. Health Quart., 23, 75–77.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Bülow, V.v., Fuchs, B., Rudolph, R. (1986). Avian Infectious Anaemia Caused by Chicken Anaemia Agent (CAA). In: McFerran, J.B., McNulty, M.S. (eds) Acute Virus Infections of Poultry. Current Topics in Veterinary Medicine and Animal Science, vol 37. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4287-5_22
Download citation
DOI: https://doi.org/10.1007/978-94-009-4287-5_22
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8405-5
Online ISBN: 978-94-009-4287-5
eBook Packages: Springer Book Archive