Abstract
After the discovery and definition of several infectious, toxic, inborn and neoplastic diseases of the gastrointestinal tract, we have remained with a group of diseases whose cause (s) have so far eluded medical research. It is likely that they do not have a single cause, that their pathogenesis is multifactorial and may require an interplay of endogenous (genetic?) and exogenous factors. Inflammatory bowel disease (IBD) is a good example of such a disorder irrespective of whether its components Ulcerative Colitis (UC) and Crohns Disease (CD) will eventually be found to have shared or separate etiologies. In the absence, so far, of a representative animal model, research has to be directed to human disease. Intensive pathologic, microbiologic and immunologic studies have not yet been rewarding. This fact, as well as the probably multifactorial nature of the disease(s) suggest epidemiologic investigation as a method that may produce relevant clues to the etiology and pathogenesis of the disease.(s)
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Gilat, T. (1986). Epidemiology of Inflammatory Bowel Disease – 1985. In: Rachmilewitz, D. (eds) Inflammatory Bowel Diseases 1986. Developments in Gastroenterology, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4269-1_6
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DOI: https://doi.org/10.1007/978-94-009-4269-1_6
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