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Occurrence and clinical manifestations of lupinosis and slaframine toxicosis

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Diagnosis of Mycotoxicoses

Part of the book series: Current Topics in Veterinary Medicine and Animal Science ((CTVM,volume 33))

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Abstract

Lupinosis is a hepatotoxicity in livestock grazing on lupin plants contaminated with a fungal parasite and saprophyte Phomopsis leptostromiformis (syn. P. rossiana). The condition is named lupinosis partly for historical reasons because it was originally thought that the disease was caused by alkaloids in the lupins [23]. However, very early work in Germany, where there were frequent outbreaks of the disease in sheep in the latter 1800s [23], suggested that a toxic fungus growing on the lupins and not lupin alkaloids was responsible for the disease. Subsequently several workers showed that the hepatotoxicity usually observed in the field was not seen in animals given the plant alkaloids. The icterus usually observed in the disease may in fact be caused by an alkaloid but the classic hepatotoxicity has been reproduced with crystalline form toxin [10].

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Authors
  1. Steven D. Aust
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Editors and Affiliations

  1. National Animal Disease Center, P.O. Box 70, 50010, Ames, Iowa, USA

    J. L. Richard  & J. R. Thurston  & 

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© 1986 Martinus Nijhoff Publishers, Dordrecht

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Aust, S.D. (1986). Occurrence and clinical manifestations of lupinosis and slaframine toxicosis. In: Richard, J.L., Thurston, J.R. (eds) Diagnosis of Mycotoxicoses. Current Topics in Veterinary Medicine and Animal Science, vol 33. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4235-6_8

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  • DOI: https://doi.org/10.1007/978-94-009-4235-6_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8380-5

  • Online ISBN: 978-94-009-4235-6

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