Abstract
In 1960 in the United Kingdom, over one hundred thousand young turkeys and ducks died in the course of a few months. Since the causal agent was unknown, and the affected animals exhibited similar symptoms, the disease was labeled ‘Turkey “X” disease’ [5]. In 1961 a toxic compound was isolated from moldy agricultural commodities [25] used as ingredients in turkey feed. Since it was produced by Aspergillus flavas Link and exhibited a characteristic blue fluorescence on TLC plates under long-wave UV light, it was named aflatoxin B1 (AFB). Shortly thereafter, toxicologic studies confirmed that AFB was the main causative agent of turkey X disease and that it was extremely hepatoxic and hepatocarcinogenic. Subsequently, another toxic blue fluorescent compound was found [2, 7] in the milk of cows fed AFB contaminated feed. It was identified as a monohydroxylated metabolite [12] of AFB [4], and was called aflatoxin M1 (AFM). Much interest has been aroused in AFM because of its frequent occurrence in milk and dairy products and its potential carcinogenicity. It is now well established that AFM is the major metabolite of AFB found in milk [2]. However, little is known about the existence of other minor AFB metabolites and their conjugates in milk [3, 19].
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References
Allcroft, R. & Carnaghan, R.B.A. 1962. Groundnut toxicity. Aspergillus flavus toxin (aflatoxin) in animal products: Preliminary communication. Vet. Ree. 74:863–864.
Allcroft, R. & Carnaghan, R.B.A. 1963. Groundnut toxicity: An examination for toxin in human food products from animals fed toxic groundnut meal. Vet. Ree. 75:259–263.
Applebaum, R.S., Brackett, R.E., Wiseman, D.W. & Marth, E.H. 1982. Responses of dairy cows to dietary aflatoxin: Feed intake and yield, toxin content, and quality of milk of cows treated with pure and impure aflatoxin. J. Dairy Sci. 65:1503–1508.
Asao, T., Buchi, G., Abdel-Kader, M.M., Chang, S.B., Wick, E.L. & Wogan, G.N. 1963. Aflatoxins B and G. J. Am. Chem. Soc. 85:1706–1707.
Blount, W.P. 1961. Turkey ‘X’ disease. Turkeys 9:52–61, 77.
Canton, J.H., Kroes, R., van Logten, M.J., van Schothorst, M., Stavenuiter, J.F.C. & Verhulsdonk, C.A.H. 1975. The carcinogenicity of aflatoxin M1 in rainbow trout. Fd. Cosmet. Toxicol. 13:441–443.
de Iongh, H., Vies, R.O. & Pelt, J.G. 1964. Milk of mammals fed an aflatoxin-containing diet. Nature 202:466–467.
Dichter, C.R. 1984. Risk estimates of liver cancer due to aflatoxin exposure from peanuts and peanut products. Fd. Cosmet. Toxicol. 22:431–437.
Fukayama, M.Y. 1979. The production, analysis, occurrence and toxicity of aflatoxin M1. M.S. thesis.
Gauch, R., Leuenberger, U. & Baumgartner, E. 1979. Rapid and simple determination of aflatoxin M1 in milk in the low parts per 1012 range. J. Chromatogr. 178:543–549.
Goto, T., Manabe, M. & Matsuura, S. 1981. Studies on self-packed column for high-performance liquid chromatographic analysis of aflatoxins and survey of aflatoxin in mixed feeds. Rept. Natl. Food Res. Inst. 38:121–125 (in Japanese).
Holzapfel, C.W., Steyn, P.S. & Purchase, I.F.H. 1966. Isolation and structure of aflatoxins M1 and M2. Tetrahedron Lett. pp. 2799–2803.
Huang, J.H. & Hsieh, D.P.H. 1984. Preparation of 14C-aflatoxin B1 of high specific activities. J. Chinese Agric. Chem. Soc. 22:27–33 (in Chinese).
Luthy, J., Zweifel, U. & Schlatter, Ch. 1980. Metabolism and tissue distribution of [14C]aflatoxin Bt in pigs. Fd. Cosmet. Toxicol. 18:253–256.
Masri, M.S., Booth, A.N. & Hsieh, D.P.H. 1974. Comparative metabolic conversion of aflatoxin B1 to M1 and Q1 by monkey, rat and chicken liver. Life Sciences 15:203–212.
Nabney, J. & Burbage, M.D. 1967. Metabolism of aflatoxin in sheep: Excretion pattern in the lactating ewe. Fd. Cosmet. Toxicol. 5:11–17.
Nishijima, M. 1984. Survey for mycotoxins in commercial foods. In: H. Kurata & Y. Ueno (eds.), Toxigenic Fungi-Their Toxins and Health Hazard. Kodansha Ltd. Tokyo, pp. 172–181.
Polzhofer, K. 1977. Determination of aflatoxins in milk and milk products. Z. Lebensmitt-Unters-Forsch. 163:175–177 (in German).
Patterson, D.S.P., Glancy, E.M. & Roberts, B.A. 1980. The ‘carry over’ of aflatoxin M1 into the milk of cows fed rations containing a low concentration of aflatoxin B1. Fd. Cosmet. Toxicol. 18:35–37.
Polan, C.E., Hayes, J.R. & Campbell, T.C. 1974. Consumption and fate of aflatoxin B1 by lactating cows. J. Agric. Food Chem. 22:635–638.
Price, R.L., Lough, O.G. & Brown, W.H. 1982. Ammoniation of whole cottonseed at atmospheric pressure and ambient temperature to reduce aflatoxin M1 in milk. J. Food Prot. 45:341–344.
Purchase, I.F.H. 1967. Acute toxicity of aflatoxins M1 and M2 in one-day-old ducklings. Fd. Cosmet. Toxicol. 5:339–342.
Rodricks, J.V. & Stoloff, L. 1977. Aflatoxin residues from contaminated feed in edible tissue of food producing animals. In: J.V. Rodricks, C.W. Hesseltine & M.A. Mehlman (eds.). Mycotoxins in Human and Animal Health. Pathotox Publishers, Inc., Park Forest South, IL. pp. 67–79.
Ruebner, B.H., Cullen, J.M., Hsieh, L. & Hsieh, D.P.H. 1983. Carcinogenicity of aflatoxin M1 and aflatoxin B1 in the male Fisher rat. Fed. Proc. 42:781.
Sargeant, K., Sheridan, A., O’Kelly, J. & Carnaghan, R.B.A. 1961. Toxicity associated with certain samples of groundnuts. Nature 192:1096–1097.
Sinnhuber, R.O., Lee, D.J., Wales, J.H., Landers, M.K. & Keyl, A.C. 1974. Hepatic carcinogenesis of aflatoxin M1 in rainbow trout (Salmo gairdneri) and its enhancement by cyclo-propene fatty acids. J. Natl. Cancer Inst. 53:1285–1288.
Stoloff, L. 1976. Occurrence of mycotoxins in foods and feeds. In: J.V. Rodricks (ed.), Mycotoxins and Other Fungal Related Food Problems. American Chemical Society, Washington, D.C., pp. 23–50.
Stoloff, L. 1977. Aflatoxins-an overview. In: J.V. Rodricks, C.W. Hesseltine & M.A. Mehlman (eds.), Mycotoxins in human and Animal Health, Pathotox Publishers, Inc., Park Forest South, IL. pp. 7–28.
Stoloff, L. 1982. Mycotoxins as potential environmental carcinogens. In: H.F. Stich (ed.), Carcinogens and Mutagens in the Environment. Vol I Food Products. CRC Press, Inc., Boca Raton, FL. pp. 97–120.
Stubblefield, R.D., Pier, A.C., Richard, J.L. & Shotwell, O.L. 1983. Fate of aflatoxins in tissues, fluids, and excrements from cows dosed orally with aflatoxin B1. Am. J. Vet. Res. 44:1750–1752.
WHO, 1979. Environmental Health Criteria 11 Mycotoxins. World Health Organization, Geneva, Switzerland.
Wogan, G.N., Edwards, G.S. & Shank, R.C. 1967. Excretion and tissue distribution of radioactivity from aflatoxin B 141 -C in rats. Cancer Res. 27:1729–1736.
Wogan, G.N. & Paglialunga, S. 1974. Carcinogenicity of synthetic aflatoxin M1 in rats. Fd. Cosmet. Toxicol. 12:381–384.
Wong, J.J. & Hsieh, D.P.H. 1976. Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential. Proc. Natl. Acad. Sci. USA 73:2241–2244.
Wyllie, T.D. & Morehouse, L.G. (eds.). 1978. Mycotoxic Fungi, Mycotoxins, Mycotoxicoses. Vol 2. Mycotoxicoses of Domestic and Lab Inc., NY.
Würzner, H.-P. 1984. Problem in food toxicology. Monatsschr. Kinderheilkd. 132:80–85 (in German).
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Goto, T., Manabe, M., Matsuura, S., Hsieh, D.D.H. (1986). Aflatoxin in milk. In: Richard, J.L., Thurston, J.R. (eds) Diagnosis of Mycotoxicoses. Current Topics in Veterinary Medicine and Animal Science, vol 33. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4235-6_10
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DOI: https://doi.org/10.1007/978-94-009-4235-6_10
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