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Radionuclide techniques in haematology

  • Chapter
Nuclear Techniques in Diagnostic Medicine

Abstract

Radionuclide methods have been part of the diagnostic armament of clinical haematologist for many years. Radioactive tracers can be bound to plasma proteins and blood cells to study the dynamics of haematopoiesis, of iron metabolism, and of destruction of blood cells. Reliable quantitative information may be obtained on plasma and red cell volume. Modern techniques also enable imaging of the sites of blood production, storage and destruction, and may assist in localizing malignant cell proliferation and sites of infection. Sophisticated kinetic studies using radioiron have dramatically broadened our knowledge on erythropoiesis and iron metabolism, both in normal and pathological conditions. Some of the methods developed through the years have proven their value in clinical practice. Others remain research tools and continue, in specialized hands, to extend our knowledge on the pathophysiology of blood. Many methods, of value in the early days of nuclear medicine, are obsolete now and have been replaced by newer, faster, safer or more accurate techniques. From the abundance of radioisotope methods in haematology a personal choice was made. For reasons of clearness most techniques of historical importance have been omitted. Also elaborative methods that offer no marked advantage over those described are omitted. Recent recommandations of ICSH (International Committee for Standardization in Haematology) panels on diagnostic application of radioisotopes in haematology are followed.

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Authors
  1. J. J. M. Marx
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  2. J. F. Verzijlbergen
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Editors and Affiliations

  1. Department of Nuclear Medicine, Utrecht University Hospital, Catharijnesingel 101, P.O. Box 16250, 3500 CG, Utrecht, The Netherlands

    P. P. van Rijk MD

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© 1986 Martinus Nijhoff Publishers, Dordrecht

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Marx, J.J.M., Verzijlbergen, J.F. (1986). Radionuclide techniques in haematology. In: van Rijk, P.P. (eds) Nuclear Techniques in Diagnostic Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4233-2_14

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  • DOI: https://doi.org/10.1007/978-94-009-4233-2_14

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