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Gallstone Disease and its Management pp 25–55Cite as

Aetiology of Cholesterol Gallstones

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Abstract

The epidemiology of gallstone disease suggests that the commonly occurring causes of cholesterol gallstones can be divided into two major categories: dietary and hormonal. The large international variations in gallstone prevalence, with gallstones being common in developed countries but rare in underdeveloped countries, suggest that factors related to lifestyle, in particular diet, have an important role in gallstone aetiology. Secondly, the well-documented increased gallstone prevalence in women, compared with men, supports a role for factors associated with the female sex, such as pregnancy and oral contraceptives. Other important risk factors, such as obesity and hypertriglyceridaemia, may themselves possibly be the results of altered dietary and hormonal risk profiles.

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References

  1. Dam, H. (1971). Determinants of cholesterol cholelithiasis in man and animals. Am. J. Med., 51, 596–613

    PubMed  CAS  Google Scholar 

  2. Hoppe-Seyler, H. (1903). Cholelithiasis. In Nothnagel’s Encyclopedia of Practical Medicine. Vol. 6, pp. 525–607. ( American Edition: W. B. Saunders )

    Google Scholar 

  3. Dam, H. and Christensen, F. (1952). Alimentary production of gallstones in hamsters. Acta Path. Microbiol. Scand., 30, 236–411

    PubMed  CAS  Google Scholar 

  4. Sampliner, R. E., Bennet, P. H., Comess, L. J. and Rose, F. A. (1970). Gallbladder disease in Pima Indians. Demonstration of high prevalence and early onset by cholecystography. N. Engl. J. Med., 283, 1358–64

    PubMed  CAS  Google Scholar 

  5. Marinovic, I., Guerra, C. and Larach, G. (1972). Incidencia de litiasis biliar en material de autopsias y analisis de composicion de los calculos. Rev. Med. Chile, 100, 1320–7

    PubMed  CAS  Google Scholar 

  6. Brett, M. and Barker, D. J. P. (1976). The world distribution of gallstones. Int. J. Epidemiol., 5, 335–41

    PubMed  CAS  Google Scholar 

  7. Burkitt, D. P. and Tunstall, M. (1975). Gallstones: geographical and chronological features. J. Trop. Med. Hyg., 78, 140–4

    PubMed  CAS  Google Scholar 

  8. Newman, H. F. and Northup, J. D. (1959). The autopsy incidence of gallstones. Int. Abst. Surg., 109, 1–13

    CAS  Google Scholar 

  9. Sarles, H., Gerolami, A. and Cros, R. C. (1978). Diet and cholesterol gallstones. A multicentre study. Digestion, 7, 121–7

    Google Scholar 

  10. Ehrstrom, R. (1942). The prevalence of gallstones and the standard of living in Finland, 1836–1939. Nordisk. Med., 14, 1559–65

    Google Scholar 

  11. Kalos, A., Delidou, A., Kosdosis, Th., Archimandritis, A., Gaganis, A. and Angelopoulos, B. (1977). The incidence of gallstones in Greece: an autopsy study. Acta Hepato-gastroenterol, 24, 20–3

    CAS  Google Scholar 

  12. Kameda, H. (1966). Gallstones: compositions, structural characteristics and geographic distribution. Third World Congress of Gastroenterology, Tokyo. Rec. Adv. Gastroenterol, 4, 117–24

    Google Scholar 

  13. Insull, W., Oiso, T. and Tsuchiya, K. (1968). Diet and nutritional status of Japanese. Am. J. Clin. Nutr., 21, 753–77

    Google Scholar 

  14. Sarles, H., Crotte, C., Gerolami, A., Mule, A., Domingo, N. and Hauton, J. (1971). The influence of calorie intake and of dietary protein on the bile lipids. Scand. J. Gastroenterol, 6, 189–91

    PubMed  CAS  Google Scholar 

  15. Shaffer, E. A. (1980). Gallstones: current concepts of pathogenesis and medical dissolution. Can. J. Surg., 23, 517–32, 557

    Google Scholar 

  16. Sarles, H., Hauton, J., Lafont, H., Teissier, N., Planche, N. and Gerolami, A. (1968). Effect of diet on the biliary cholesterol concentration in normals and gallstone patients. Clin. Chim. Acta, 19, 147–55

    Google Scholar 

  17. Bennion, L. J. and Grundy, S. M. (1975). Effects obesity and caloric intake on biliary lipid metabolism in man. J. Clin. Invest., 56, 996–1011

    PubMed  CAS  Google Scholar 

  18. Dam, H., Kruse, I., Jensen, K. and Kallehauge, H. E. (1967). Studies on human bile. II. Influence of two different fats on the composition of human bile. Scand. J. Clin. Lab. Invest., 19, 367–78

    PubMed  CAS  Google Scholar 

  19. Schlierf, G., Nikolaus, T., Stiehl, A. et al. (1979). Zur Wirkung lipidspiegelsenkender kostforman auf gailenlipide und piasmalipoproteine bei normalpersonen. Schweiz Med. Wschr., 109, 1743–7

    PubMed  CAS  Google Scholar 

  20. Grundy, S. M. (1975). Effects of polyunsaturated fats on lipid metabolism in patients with hypertriglyceridemia. J. Clin. Invest., 55, 269–82

    PubMed  CAS  Google Scholar 

  21. Lewis, B. (1958). Effect of certain dietary oils on bile-acid secretion and serum cholesterol. Lancet, 1, 1090–2

    PubMed  CAS  Google Scholar 

  22. Watanabe, N., Gimbel, N. S. and Johnston, C. G. (1962). Effect of polyunsaturated and saturated fatty acids on the cholesterol holding capacity of human bile. Arch. Surg., 85, 136–41

    PubMed  CAS  Google Scholar 

  23. Grundy, S. M. and Metzger, A. L. (1972). A physiological method for estimation of hepatic biliary lipids in man. Gastroenterology, 62, 1200–17

    PubMed  CAS  Google Scholar 

  24. Andersen, E. and Hellstrom, K. (1980). Influence of fat-rich versus carbohydrate-rich diets on bile acid kinetics, biliary lipids, and net-steroid balance in hyperlipidemic subjects. Metabolism, 29, 400–9

    PubMed  CAS  Google Scholar 

  25. Hepner, G. W. (1975). Effect of decreased gallbladder stimulation on enterohepatic cycling and kinetics of bile acids. Gastroenterology, 68, 1574–81

    PubMed  CAS  Google Scholar 

  26. Aschoff, L. and Bacmeister, A. (1909). Die Cholelithiasis. (Jena: Fischer)

    Google Scholar 

  27. DenBesten, L., Conner, W. E. and Bell, S. (1973). The effect of dietary cholesterol on the composition of human bile. Surgery, 73, 266–73

    PubMed  CAS  Google Scholar 

  28. Lee, D. W. T., Gilmore, C. J., Bonorris, G. et al. (1985). Effect of dietary cholesterol on biliary lipids in patients with gallstones and normal subjects. Am. J. Clin. Nutr., 42, 414–20

    PubMed  CAS  Google Scholar 

  29. Maudgal, D. P., Bird, R., Blackwood, W. S. and Northfield, T. C. (1978). Low-cholesterol diet: enhancement of effect of CDCA in patients with gallstones. Br. Med. J., 2, 851–3

    PubMed  CAS  Google Scholar 

  30. Dam, H., Prange, I., Jensen, K., Kallehauge, H. E. and Fenger, H. J. (1971). Studies on human bile. IV. Influence of ingestion of cholesterol in the form of eggs on the composition of bile in healthy subjects. Z. Ernaehrungswiss., 10, 178–87

    CAS  Google Scholar 

  31. Sarles, E., Crotte, C., Gerolami, A., Mule, A., Domingo, N. and Hauton, J. (1970). Influence of cholestyramine, bile salt, and cholesterol feeding on the lipid composition of hepatic bile in man. Scand. J. Gastroenterol, 5, 603–8

    PubMed  CAS  Google Scholar 

  32. Andersen, E. and Hellstrom, K. (1974). The effects of cholesterol feeding on bile acid kinetics and biliary lipids in normolipidemic and hypertriglyceridemic subjects. J. Lipid Res., 20, 1020–7

    Google Scholar 

  33. Wilson, J. D. and Lindsey, C. A. (1965). Studies on the influence of dietary cholesterol on cholesterol metabolism in the isotopic steady state in man. J. Clin. Invest., 44, 1805–14

    PubMed  CAS  Google Scholar 

  34. Quintao, E., Grundy, S. M. and Ahrens, E. H. (1971). Effects of dietary cholesterol on the regulation of total body cholesterol in man. J. Lipid Res., 12, 1233–47

    Google Scholar 

  35. Nestel, P. J. and Poyser, A. (1976). Changes in cholesterol synthesis and excretion when cholesterol intake is increased. Metabolism, 25, 1591–9

    PubMed  CAS  Google Scholar 

  36. Harper, H. A., Rodwell, V. W. and Mayes, P. A. (1977). Review of Physiological Chemistry. 6th Edn. ( Los Altos: Lange Medical )

    Google Scholar 

  37. Heaton, K. W. (1972). Bile Salts in Health and Disease. ( Edinburgh: Churchill Livingstone )

    Google Scholar 

  38. Heaton, K. W., Emmett, P. M., Henry, C. L., Thornton, J. R., Manhire, A. and Hartog, M. (1983). Not just fibre - the nutritional consequences of refined carbohydrate foods. Human Nutr.: Clin. Nutr., 37C, 31–5

    CAS  Google Scholar 

  39. Cleave, T. L. (1974). The Saccharine Disease. ( Bristol: John Wright and Sons )

    Google Scholar 

  40. Bennion, L. J. and Grundy, S. M. (1977). Effects of diabetes mellitus on cholesterol metab-olism in man. N. Engl. J. Med., 296, 1365–71

    PubMed  CAS  Google Scholar 

  41. Swan, D. C., Davidson, P. and Albrink, M. J. (1966). Effect of simple and complex carbohydrates on plasma non-esterified fatty acids, plasma sugar, and plasma insulin during oral carbohydrate tolerance tests. Lancet, 1, 60–3

    PubMed  CAS  Google Scholar 

  42. Wahlqvist, M. L., Wilmshurst, E. G., Murton, C. R. and Richardson, C. N. (1978). The effect of chain length of glucose absorption and the related metabolic response. Am. J. Clin. Nutr., 31, 1998–2001

    PubMed  CAS  Google Scholar 

  43. Crapo, P. A., Scarlett, J. A. and Kolterman, O. G. (1982) Comparison of the metabolic responses to fructose and sucrose sweetened foods. Am. J. Clin. Nutr., 36, 256–61

    PubMed  CAS  Google Scholar 

  44. Szanto, S, and Yudkin, J. (1969). The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers. Postgrad. Med. J., 45, 602–7

    PubMed  CAS  Google Scholar 

  45. Reiser, S., Handler, H. B., Gardner, L. B., Hallfrisch, J. G., Michaelis, O. E. and Prather, E. S. (1979). Isocaloric exchange of dietary starch and sucrose in humans. II. Effect on fasting blood insulin, glucose and glucagon and on insulin and glucose response to a sucrose load. Am. J. Clin. Nutr., 32, 2206–16

    PubMed  CAS  Google Scholar 

  46. Reiser, S., Bohn, E., Hallfrisch, J., Michaelis, O. E., Keeney, M. and Prather, E. S. (1981). Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Am. J. Clin. Nutr., 34, 2348–58

    PubMed  CAS  Google Scholar 

  47. Coulston, A., Greenfield, M. S., Kraemer, F. B. et al. (1981). Effect of differences in sources of dietary carbohydrates on plasma glucose and insulin responses to meals in patients with impaired carbohydrate tolerance. Am. J. Clin. Nutr., 34, 2716–20

    PubMed  CAS  Google Scholar 

  48. Cahlin, E., Jonsson, J., Nilsson, S. and Schersten, T. (1973). Biliary lipid composition in normolipidemic and prebeta hyperlipoproteinemic gallstone patients. Influence of sucrose feeding of the patients on the biliary lipid composition. Scand. J. Gastroenterol, 8, 449–56

    PubMed  CAS  Google Scholar 

  49. Thornton., R. R., Emmett, P. M. and Heaton, K. W. (1983). Diet and gallstones: effects of refined and unrefined carbohydrate diets on bile cholesterol saturation and bile acid metabolism. Gut, 24, 2–6

    Google Scholar 

  50. Werner, D., Emmett, P. M. and Heaton, K. W. (1984). Effects of dietary sucrose on factors influencing cholesterol gallstone formation. Gut, 25, 269–74

    PubMed  CAS  Google Scholar 

  51. Burkitt, D. P. (1973). Some diseases characteristic of modern western civilization. Br. Med. J., 1, 274–8

    PubMed  CAS  Google Scholar 

  52. Trowell, H. (1978). The development of the concept of dietary fiber in human nutrition. Am. J. Clin. Nutr., 31, S3–S11

    PubMed  CAS  Google Scholar 

  53. Pomare, E. W., Heaton, K. W., Low-Beer, T. S. and Espiner, H. J. (1976). The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients. Am. J. Dig. Dis., 21, 521–6

    PubMed  CAS  Google Scholar 

  54. McDougall, R. M., Yakymyshyn, L., Walker, K. and Thorston, O. G. (1978). Effect of wheat bran on serum lipoproteins and biliary lipids. Can. J. Surg., 21, 433–5

    PubMed  CAS  Google Scholar 

  55. Watts, J. McK., Jablonski, P. and Toouli, J. (1978). The effect of added bran to the diet on the saturation of bile in people without gallstones. Am. J. Surg., 135, 321–4

    PubMed  CAS  Google Scholar 

  56. Wicks, A. C. B., Yeates, J. and Heaton, K. W. (1978). Bran and bile time-course of changes in normal young men given a standard dose. Scand. J. Gastroenterol, 13, 289–92

    PubMed  CAS  Google Scholar 

  57. Huijbregts, A. W. M., Van Berge-Henegouwen, G. P., Hectors, M. P. C., Van Schaik, A. and Van der Werf, S. D. J. (1980). Effects of a standardized wheat bran preparation on biliary lipid composition and bile acid metabolism in young healthy males. Eur. J. Clin. Invest., 10, 451–8

    PubMed  CAS  Google Scholar 

  58. Tarpila, S., Miettinen, T.A. and Metsaranta, L. (1978). Effects of bran on serum cholesterol, faecal mass, fat, bile acids and neutral sterols, and biliary lipids in patients with diverticular disease of the colon. Gut, 19, 137–45

    PubMed  CAS  Google Scholar 

  59. Thornton, J. R. and Heaton, K. W. (1981). Do colonic bacteria contribute to cholesterol gallstone formation? Effects of lactulose on bile. Br. Med.J. 282, 1018–20

    CAS  Google Scholar 

  60. Pomare, E.W. and Heaton, K. W. (1973). Alteration of bile salt metabolism by dietary fibre (bran). Br. Med. J., 4, 262–4

    PubMed  CAS  Google Scholar 

  61. Meyer, P. D., DenBesten, L. and Mason, E. E. (1979). The effects of a high-fibre diet on bile acid pool size, bile acid kinetics and biliary lipid secretory rates in the morbidly obese. Surgery, 85, 311–6

    PubMed  CAS  Google Scholar 

  62. Brydon, W. G., Borup-Christensen, S., Van der Linden, W. and Eastwood, M. A. (1979). The effect of dietary psyllium hydrocolloid and lignin on bile. Z. Ernaehrungswiss., 18, 77–80

    CAS  Google Scholar 

  63. Kelsay,J. (1978). A review of research on effects of fiber intake on man. Am. J. Clin. Nutr., 31, 142–59

    Google Scholar 

  64. Redinger, R. N. and Grace, D. M. (1976). Cholestyramine induced cholesterol gallstones in the baboon. Clin. Res., 24, 666A

    Google Scholar 

  65. Nestel, P. J., Simons, L. A. and Homma, Y. (1976). Effects of ethanol on bile acid and cholesterol metabolism. Am. J. Clin. Nutr., 29, 1007–15

    PubMed  CAS  Google Scholar 

  66. Marin, G. A., Ward, N. L. and Fischer, R. (1973). Effects of ethanol on pancreatic biliary secretions in humans. Am. J. Dig. Dis., 18, 825–33

    PubMed  CAS  Google Scholar 

  67. Bouchier, I. A. D. (1969). Postmortem study of the frequency of gallstones in patients with cirrhosis of the liver. Gut, 10, 705–10

    PubMed  CAS  Google Scholar 

  68. Nicholas, P., Rinaudo, P. A. and Conn, H. O. (1972). Increased incidence of cholelithiasis in Laennec’s cirrhosis. Gastroenterology, 63, 112–21

    PubMed  CAS  Google Scholar 

  69. Vlahcevic, Z. R., Yoshida, T., Juttijudata, P., Bell, C. C. and Swell, L. (1973). Bile acid metabolism in cirrhosis. III. Biliary lipid secretion in patients with cirrhosis and its relevance to gallstone formation. Gastroenterology, 64, 298–303

    PubMed  CAS  Google Scholar 

  70. Schwartz, C. C., Almond, H. R., Vlahcevic, Z. R. and Swell, L. (1979). Bile acid metabolism in cirrhosis. V. Determination of biliary lipid secretion rates in patients with advanced cirrhosis. Gastroenterology, 77, 1177–82

    PubMed  CAS  Google Scholar 

  71. Thornton, J., Symes, C. and Heaton, K. (1983). Moderate alcohol intake reduces bile cholesterol saturation and raises HDL cholesterol. Lancet, 2, 819–22

    PubMed  CAS  Google Scholar 

  72. Whiting, M. J., Down, R. H. L. and Watts, J. McK. (1981). Precision and saturation index of duodenal bile. Gastroenterology, 80, 533–8

    PubMed  CAS  Google Scholar 

  73. Sarles, H., Chalvet, H., Ambrosi, L. and D’Ortoli, G. (1957). Etude statistique des facteurs dietetiques dans la pathogenie de la lithiase biliare humaine. Sem. Hop. Paris, 58, 3424–8

    Google Scholar 

  74. Hauton,J. (1966). Cholelithiasis. Third World Congress of Gastroenterology, Tokyo. Rec. Adv. Gastroenterol., 4, 109–16

    Google Scholar 

  75. Sarles, H., Chabert, C., Pommeau, Y., Save, E., Mouret, H. and Gerolami, A. (1969). Diet and cholesterol gallstones. A study of 101 patients with cholelithiasis compared to 101 matched controls. Am. J. Dig. Dis., 14, 531–7

    PubMed  CAS  Google Scholar 

  76. Sarles, H., Gerolami, A. and Bord, A. (1978). Diet and cholesterol gallstones. A further study. Digestion, 17, 128–34

    PubMed  CAS  Google Scholar 

  77. Coste, T., Karsenti, P., Berta, J. l., Cubeau, J. and Guilloud-Bataille, M. (1979). Facteurs dietetiques de la lithiase biliare: comparaison de l’alimentation d’un groupe temion. Gastroenterol. Clin. Biol., 3, 417–24

    PubMed  CAS  Google Scholar 

  78. Burnett, W. (1971). The epidemiology of gallstones. Tijdschr. Gastroenterol., 14, 79–89

    CAS  Google Scholar 

  79. Wheeler, M., Hills, L. L. and Laby, B. (1970). Cholelithiasis: a clinical and dietary survey. Gut, 11, 430–7

    PubMed  CAS  Google Scholar 

  80. Smith, D. A. and Gee, M. I. (1979). A dietary survey to determine the relationship between diet and cholelithiasis. Am. J. Clin. Nutr., 32, 1519–26

    PubMed  CAS  Google Scholar 

  81. Williams, C. N. and Johnston, J. L. (1980). Prevalence of gallstones and risk factors in Caucasian women in a rural Canadian community. Can. Med. Assoc.J., 120, 664–8

    Google Scholar 

  82. Alessandrini, A., Fusco, M. A., Gatti, E. and Rossi, P. A. (1982). Dietary fibres and cholesterol gallstones: a case control study. Ital. J. Gastroenterol, 14, 156–8

    Google Scholar 

  83. Scragg, R. K. R., McMichael, A. J. and Baghurst, P. A. (1984). Diet, alcohol and relative weight in gallstone disease: a case-control study. Br. Med. J., 228, 1113–9

    Google Scholar 

  84. Reid, J. M., Fullmer, S. D., Pettigrew, K. D. et al. (1971). Nutrient intake of Pima Indian women: relationships to diabetes mellitus and gallbladder disease. Am. J. Clin. Nutr., 24, 1281–9

    PubMed  CAS  Google Scholar 

  85. Friedman, G. D., Kannel, W. B. and Dawber, T. R. (1966). The epidemiology of gallbladder disease: observations in the Framingham Study. J. Chron. Dis., 19, 273–92

    PubMed  CAS  Google Scholar 

  86. Block, G. (1982). A review of validations of dietary assessment methods. Am. J. Epidemiol., 115, 492–505

    PubMed  CAS  Google Scholar 

  87. Attili, A. F. and the GREPCO Group (1984). Dietary habits and cholelithiasis. In Capocaccia, L., Ricci, G., Angelico, F., Angelico, M. and Attili, A. F. (eds.) Epidemiology and Prevention of Gallstone Disease, pp. 175–81. ( Lancaster, England: MTP Press )

    Google Scholar 

  88. Klatsky, A. L., Friedman, G. D. and Siegelaub, A. B. (1981). Alcohol use and cardiovascular disease: the Kaiser-Permanente experience. Circulation, 64, suppl. III, 32–41

    Google Scholar 

  89. Johnston, J. L., Williams, C. N. and Weldon, K. L. M. (1977). Nutrient intake and meal patterns of Micmac Indian and Caucasian women in Shubenacadie, NS. Can. Med. Assoc. J., 116, 1356–9

    PubMed  CAS  Google Scholar 

  90. Pixley, F., Wilson, D., McPherson, K. and Mann, J. (1985). Effect of vegetarianism on development of gallstones in women. Br. Med. J., 291, 11–12

    CAS  Google Scholar 

  91. Sturdevant, R. A. L., Pearce, M. L. and Dayton, S. (1973). Increased prevalence of cholelithiasis in men ingesting a serum-cholesterol-lowering diet. N. Engl J. Med., 228, 24–7

    Google Scholar 

  92. Miettinen, M., Turpeinen, O., Karvonen, M. J., Paavilainen, E. and Elosuo, R. (1976). Prevalence of cholelithiasis in men and women ingesting a serum-cholesterol-lowering diet. Ann. Clin. Res., 8, 111–6

    PubMed  CAS  Google Scholar 

  93. Gross, D. M. B. (1929). A statistical study of cholelithiasis. J. Pathol. Bacteriol., 32, 503–26

    Google Scholar 

  94. Zahor, Z (1976). Atherosclerosis in relation to cholelithiasis and cholesterolosis. Bull. WHO, 53, 531–7

    PubMed  CAS  Google Scholar 

  95. Diehl, A. K., Stern, M. P., Ostrower, V. S. and Friedman, P. C. (1980). Prevalence of clinical gallbladder disease in Mexican-American, Anglo and Black Women. South. Med. J., 73, 438–43

    PubMed  CAS  Google Scholar 

  96. Tucker, L. E., Tangedahl, T. N. and Newmark, S. R. (1982). Prevalence of gallstones in obese caucasian American women. Int. J. Obesity, 6, 247–51

    CAS  Google Scholar 

  97. Van der Linden, W. (1962). Some biological traits in female gallstone-disease patients. Acta Chir. Scand., suppl. 269

    Google Scholar 

  98. Horn, G. (1956). Observations on the aetiology of cholelithiasis. Br. Med. J., 2, 732–7

    PubMed  CAS  Google Scholar 

  99. Bernstein, R. A., Werner, L. H. and Rimm, A. A. (1973). Relationship of gallbladder disease to parity, obesity and age. Health Serv. Rep., 88, 925–36

    PubMed  CAS  Google Scholar 

  100. Honore, L. H. (1980). Cholesterol cholelithiasis in adolescent females. Its connection with obesity, parity and oral contraceptive use - a retrospective study of 31 cases. Arch. Surg., 115, 62–4

    PubMed  CAS  Google Scholar 

  101. Nestel, P. J., Whyte, H. M. and Goodman, D. S. (1969). Distribution and turnover of cholesterol in humans. J. Clin. Invest., 48, 982–91

    PubMed  CAS  Google Scholar 

  102. Miettinen, T. A. (1971). Cholesterol production in obesity. Circulation, 44, 842–50

    PubMed  CAS  Google Scholar 

  103. Grundy, S. M., Duane, W. C., Adler, R. D., Aron, J. M. and Metzger, A. L. (1974). Biliary lipid outputs in young women with cholesterol stones. Metabolism, 23, 67–73

    PubMed  CAS  Google Scholar 

  104. Mabee, T. M., Meyer, P., DenBesten, L. and Mason, E. E. (1976). The mechanism of increased gallstone formation in obese human subjects. Surgery, 79, 460–8

    PubMed  CAS  Google Scholar 

  105. Angelin, B., Einarsson, K., Ewerth, S. and Leijd, B. (1981). Biliary lipid composition in obesity. Scand. J. Gastroenterol, 16, 1015–9

    PubMed  CAS  Google Scholar 

  106. Sorensen, T. I. A., Jensen, L. I., Klein, H. C. et al. (1980). Risk of gallstone formation after jejunoileal bypass increases more with a 1:3 than a 3:1 jejunoileal ratio. Scand. J. Gastroenterol, 15, 979–84

    PubMed  CAS  Google Scholar 

  107. Krag, E. and Hojgaard, L. (1981). Bile acid metabolism after intestinal bypass operation. Int. J. Obesity, 5, 519–25

    CAS  Google Scholar 

  108. Layde, P. M., Vessey, M. P. and Yeates, D. (1982). Risk factors for gallbladder disease: a cohort study of young women attending family planning clinics. J. Epidemiol Commun. Health, 36, 274–8

    CAS  Google Scholar 

  109. Ahlberg, J. (1979). Serum lipid levels and hyperlipoproteinaemia in gallstone patients. Acta Chir. Scand., 145, 373–7

    PubMed  CAS  Google Scholar 

  110. Angelico, F. and the GREPCO Group (1984). Factors associated with gallstone disease: observations in the GREPCO study. In Capocaccia, L., Ricco, G., Angelico, F., Angelico, M. and Attili, A. F. (eds.) Epidemiology and Prevention of Gallstone Disease, pp. 185 - 92. ( Lancaster, England: MTP Press )

    Google Scholar 

  111. Scragg, R. K. R., McMichael, A. J. and Seamark, R. F. (1984). Oral contraceptives, pregnancy and endogenous oestrogen in gallstone disease - a case-control study. Br. Med. J., 288, 1795–9

    CAS  Google Scholar 

  112. Comess, L. J., Bennett, P. H. and Burch, T. A. (1967). Clinical gallbladder disease in Pima Indians. N. Engl J. Med., 277, 894–8

    PubMed  CAS  Google Scholar 

  113. Thistle, J. L., Eckhart, K. L., Nensel, R. E. et al (1971). Prevalence of gallbladder disease among Chippewa Indians. Mayo Clin. Proc., 46, 603–8

    PubMed  CAS  Google Scholar 

  114. Williams, C. N., Johnston, J. L. and Weldon, K. L. M. (1977). Prevalence of gallstones and gallbladder disease in Canadian Micmac Indian women. Can. Med. Assoc. J., 117, 758–60

    PubMed  CAS  Google Scholar 

  115. Robertson, H. E. and Dochat, G. R. (1944). Pregnancy and gallstones: collective review. Int. Abstr. Surg., 78, 193–204

    Google Scholar 

  116. Everson, G. T., McKinley, C., Lawson, M., Johnson, M. and Kern, F. (1982). Gallbladder function in the human female: effect of the ovulatory cycle, pregnancy and contraceptive steroids. Gastroenterology, 82, 711–9

    PubMed  CAS  Google Scholar 

  117. Dokert, B., Jaross, W., Schentke, K., Trubsbach, A. and Sarembe, B. (1978). Schwangerschaft, orale hormonale kontrazeption und gallenlipidzusammensetzung. Dtsch. Gesundheitswesen, 33, 1153–5

    CAS  Google Scholar 

  118. Boston Collaborative Drug Surveillance Programme (19 73). Oral contraceptives and venous thromboembolic disease, surgically confirmed gallbladder disease, and breast tumours. Lancet, 1, 1399–404

    Google Scholar 

  119. Stolley, P. D., Tonascia, J. A., Tockman, M. S., Sartwell, P. E., Rutledge, A. H. and Jacobs, M. P. (1975). Thrombosis with low-estrogen oral contraceptives. Am. J. Epidemiol, 102, 197–208

    PubMed  CAS  Google Scholar 

  120. Vessey, M., Doll, R., Peto, R., Johnson, B. and Wiggins, P. (1976). A long-term follow-up study of women using different metods of contraception - an interim report. J. Biosoc. Sci., 8, 373–427

    PubMed  CAS  Google Scholar 

  121. Boston Collaborative Drug Surveillance Program (1974). Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. N. Engl J. Med., 290, 15–9

    Google Scholar 

  122. Coronary Drug Project Research Group (1977). Gallbladder disease as a side effect of drugs influencing lipid metabolism. N. Engl J. Med., 296, 1185 – 90

    Google Scholar 

  123. Pertsemlidis, D., Panveliwalla, D. and Ahrens, E. H. (1974). Effects of clofibrate and of an estrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man. Gastroenterology, 66, 565–73

    PubMed  CAS  Google Scholar 

  124. Bennion, L. J., Ginsberg, R. L., Garnick, M. B. and Bennett, P. H. (1976). Effects of oral contraceptives on the gallbladder bile of normal women. N. Engl J. Med., 294, 189–92

    PubMed  CAS  Google Scholar 

  125. Bennion, L. J., Mott, D. M. and Howard, B. V. (1980). Oral contraceptives raise the cholesterol saturation of bile by increasing biliary cholesterol secretion. Metabolism, 29, 18–22

    PubMed  CAS  Google Scholar 

  126. Ramcharan, S., Pellegrin, F. A., Ray, R. and Hsu, J-P. (1981). The Walnut Creek Contraceptive Drug Study. Vol. 3, pp. 151–2. ( Bethesda: National Institutes of Health )

    Google Scholar 

  127. Royal College of General Practitioners’ Oral Contraception Study (1982). Oral contraceptives and gallbladder disease. Lancet, 2, 957–9

    Google Scholar 

  128. Evron, S., Frankel, M. and Diamant, Y. (1982). Biliary disease in young women and its association with pregnancy or oral contraceptives. Int. Surg., 67, 448–50

    PubMed  CAS  Google Scholar 

  129. Scragg, R. K. R. and McMichael, A. J. (1984). Letter. Br. Med. J., 289, 252

    Google Scholar 

  130. Everson, R. B., Byar, D. P. and Bischoff, A. J. (1982). Estrogen predisposes to cholecystectomy but not to stones. Gastroenterology, 82, 4–8

    PubMed  CAS  Google Scholar 

  131. Olefsky, J. M., Farquhar, J. W. and Reaven, G. M. (1974). Reappraisal of the role of insulin in hypertriglyceridemia. Am. J. Med., 57, 551–60

    PubMed  CAS  Google Scholar 

  132. Braunsteiner, H., Di Pauli, R., Sailer, S. and Sandhofer, F. (1966). Cholelithiasis und latent diabetische stoffwechsellage. Schweiz Med. Wochenschr., 96, 44–6

    PubMed  CAS  Google Scholar 

  133. Kadziolka, R., Nilsson, S. and Schersten, T. (1977). Prevalence of hyperlipoproteinaemia in men with gallstone disease. Scand. J. Gastroenterol, 12, 353–5

    PubMed  CAS  Google Scholar 

  134. Scragg, R. K. R., Calvert, G. D. and Oliver, J. R. (1984). Plasma lipids and insulin in gallstone disease: a case-control study. Br. Med. J., 289, 521–5

    CAS  Google Scholar 

  135. Einarsson, K., Hellstrom, K. and Kallner, M. (1975). Gallbladder disease in hyper-lipoproteinaemia. Lancet, 1, 484–7

    PubMed  CAS  Google Scholar 

  136. Van der Linden, W. and Bergman, F. (1977). An analysis of data on human hepatic bile. Relationship between main bile components, serum cholesterol and serum triglycerides. Scand. J. Clin. Lab. Invest., 37, 741–7

    PubMed  Google Scholar 

  137. Hassan, T. J., Maqsood, R. and Zuberi, S. J. (1979). Lipid patterns in cholelithiasis. J. Pak. Med. Assoc., 29, 93–6

    PubMed  CAS  Google Scholar 

  138. Thornton, J. R., Heaton, K. W. and MacFarlane, D. G. (1981). A relation between high- density-lipoprotein cholesterol and bile cholesterol saturation. Br. Med. J., 283, 1352–4

    CAS  Google Scholar 

  139. Marks, J. W., Cleary, P. A. and Albers, J. J. (1984). Lack of correlation between serum lipoproteins and biliary cholesterol saturation in patients with gallstones. Dig. Dis. Sci., 29, 1118–22

    PubMed  CAS  Google Scholar 

  140. Hove, E. and Geill, T. (1968). Serum cholesterol and incidence of gallstones. Geriatrics, 23, 114–8

    PubMed  CAS  Google Scholar 

  141. Albers, J. J., Grundy, S. M., Cleary, P. A., Small, D. M., Lachin, J. M. and Schoenfield, L. J. (1982). National Cooperative Gallstone Study: the effect of chenodeoxycholic acid on lipoproteins and apolipoproteins. Gastroenterology, 82, 638–46

    PubMed  CAS  Google Scholar 

  142. Sievers, M. L. (1968). Serum cholesterol levels in southwestern American Indians. J. Chron. Dis. 21, 107–15

    PubMed  CAS  Google Scholar 

  143. Savage, P. J., Hamman, R. F., Bartha, G., Dippe, S. E., Miller, M. and Bennett, P. H. (1976). Serum cholesterol levels in American (Pima) Indian children and adolescents. Pediatrics, 58, 274–82

    PubMed  CAS  Google Scholar 

  144. Thorbjarnarson, B. J. (1969). Lipid in blood and bile from the normal and the person with cholelithiasis. Arch. Surg., 98, 372–4

    PubMed  CAS  Google Scholar 

  145. Maqsood, R., Zuberi, S. J., Nizami, H. M. and Chaudhry, S. A. (1976). Gallstone composition and biochemical alterations in the serum of patients with cholelithiasis. J. Pak. Med. Assoc., 28, 167–8

    Google Scholar 

  146. Angelico, M. and the GREPCO Group (1984). Relationships between serum lipids and cholelithiasis: observations in the GREPCO study. In Capocaccia, L., Ricci, G., Angelico, F., Angelico, M. and Attili, A. F. (eds.) Epidemiology and Prevention of Gallstone Disease, pp. 77–84. ( Lancaster, England: MTP Press )

    Google Scholar 

  147. Petitti, D. B., Friedman, G. D. and Klatsky, A. L. (1981). Association of a history of gallbladder disease with a reduced concentration of high density lipoprotein cholesterol. N. Engl. J. Med., 304, 1396–8

    PubMed  CAS  Google Scholar 

  148. Carlson, L. A. and Ericsson, M. (1975). Quantitative and qualitative serum lipoprotein analysis. Part 2. Studies in male survivors of myocardial infarction. Atherosclerosis, 21, 435–50

    PubMed  CAS  Google Scholar 

  149. Stout, R.W., Balmer, J. P., Henry, R. W. and Buchanan, K. D. (1978). Plasma lipids and gastrointestinal hormones in subjects with gallstones. Horm. Metab. Res., 10, 357–8

    PubMed  CAS  Google Scholar 

  150. Kolterman, O. G., Gray, R.S., Griffin, J. et al. (1981). Receptor and post-receptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J. Clin. Invest., 68, 957–69

    PubMed  CAS  Google Scholar 

  151. Olefsky, J. M. and Kolterman, O. G. (1980). In vivo studies of insulin resistance in human obesity. In Bjoratop, P., Cairella, M. and Howard, A. N. (eds.) Recent Advances in Obesity Research. Vol. 3, pp. 254–67. ( London: John Libbey )

    Google Scholar 

  152. Ponz de Leon, M., Ferenderes, R. and Carulli, N. (1978). Bile lipid composition and bile acid pool size in diabetes. Am. J. Dig. Dis., 23, 710–16

    Google Scholar 

  153. Kajiyama, G., Oyamada, K., Nakao, S. and Miyoshi, A. (1981). The effect of diabetes mellitus and its treatment on the lithogenicity of bile in man. Hiroshima J. Med. Sci., 30, 221–7

    PubMed  CAS  Google Scholar 

  154. Haber, G. B. and Heaton, K. W. (1979). Lipid composition of bile in diabetes and obesity- matched controls. Gut, 20, 518–22

    PubMed  CAS  Google Scholar 

  155. Castelli, W. P., Doyle, J. T., Gordon, T. etal (1977). Alcohol and blood lipids. The cooperative lipoprotein phenotyping study. Lancet, 2, 153–5

    PubMed  CAS  Google Scholar 

  156. Wynn, V., Adams, P. W., Godsland, I. et al. (1979). Comparison of effects of different combined oral-contraceptive formulations on carbohydrate and lipid metabolism. Lancet, 1, 1045–9

    PubMed  CAS  Google Scholar 

  157. Puavilai, G., Drobney, E. C., Domont, L. A. and Baumann, G. (1982). Insulin receptors and insulin resistance in human pregnancy: evidence for a postreceptor defect in insulin action. J. Clin. Endocrinol. Metab., 54, 247–53

    PubMed  CAS  Google Scholar 

  158. Williams, P. F., Simons, L. A. and Turtle, J. R. (1976). Plasma lipoproteins in pregnancy. Horm. Res., 7, 83–90

    PubMed  CAS  Google Scholar 

  159. Bailey, C. J. and Ahmed-Sorour, H. (1980). Role of ovarian hormones in the long-term control of glucose homeostasis: effects on insulin secretion. Diabetologia, 19, 475–81

    PubMed  CAS  Google Scholar 

  160. Kim, H. J. and Kalkhoff, R. K. (1975). Sex steroid influence in triglyceride metabolism. J. Clin. Invest., 56, 888–96

    PubMed  CAS  Google Scholar 

  161. Sodhi, H. S. and Kudchodkar, B. J. (1973). Correlating metabolism of plasma and tissue-cholesterol with that of plasma-lipoproteins. Lancet, 1, 513–9

    PubMed  CAS  Google Scholar 

  162. Shaffer, E. A. and Small, D. M. (1977). Biliary lipid secretion in cholesterol gallstone disease: the effect of cholecystectomy and obesity. J. Clin. Invest., 59, 828–40

    PubMed  CAS  Google Scholar 

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  1. R. K. R. Scragg
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  1. General Hospital, Bishop Auckland, UK

    Malcolm C. Bateson (Consultant Physician and Specialist in Gastroenterology) (Consultant Physician and Specialist in Gastroenterology)

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Scragg, R.K.R. (1986). Aetiology of Cholesterol Gallstones. In: Bateson, M.C. (eds) Gallstone Disease and its Management. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4173-1_2

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  • DOI: https://doi.org/10.1007/978-94-009-4173-1_2

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