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HLA-DR Antigen Expression and Autoimmunity

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Book cover Immunology of Endocrine Diseases

Part of the book series: Immunology and Medicine ((IMME,volume 3))

Abstract

Products of the major histocompatibility complex (MHC) of genes play several key roles in the autoimmune response. Besides being predominantly responsible for the rejection of tissue grafts and graft-versus-host reactions, molecules encoded by MHC genes are directly involved in the recognition of antigen by T-cells. The MHC also determines to a great extent whether or not a particular antigen will evoke an immune response. The chapter begins with a synopsis of MHC antigens and their involvement in the normal immune response, together with a review of the factors involved in antigen presentation. This is followed by a summary of the recent studies which show that a wide variety of cells, including those from endocrine tissues, may express MHC class II antigens, like HLA-DR, under certain conditions. In the last section, the possible consequences of this phenomenon are discussed with regard to endocrine autoimmunity.

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Authors
  1. A. P. Weetman
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Editors and Affiliations

  1. Department of Medicine, University of Wales College of Medicine, Health Park, Cardiff, Wales, CF4 4XN, UK

    Alan M. McGregor (Senior Lecturer and Honorary Consultant Physician) (Senior Lecturer and Honorary Consultant Physician)

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© 1986 MTP Press Limited

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Weetman, A.P. (1986). HLA-DR Antigen Expression and Autoimmunity. In: McGregor, A.M. (eds) Immunology of Endocrine Diseases. Immunology and Medicine, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4171-7_8

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  • DOI: https://doi.org/10.1007/978-94-009-4171-7_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8352-2

  • Online ISBN: 978-94-009-4171-7

  • eBook Packages: Springer Book Archive

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