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Physiology and Pathology of Immunoglobulins in the Fetus and Child

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Book cover Immunoglobulins in Health and Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 1))

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Abstract

The human fetus normally becomes immunocompetent long before birth, although it remains relatively inactive immunologically. The present chapter considers the normal development of humoral immunity and the consequences of antigenic stimulation of the fetus and child at various stages of development. Important therapeutic implications in a variety of paediatric diseases will also be discussed.

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References

  1. Vogler, L. B. and Lawton, A. R. (1985). Ontogeny of B-cells and humoral immune functions. Clin. Immunol. Allergy, 5, 235–51

    Google Scholar 

  2. Kehrl, J. H., Muraguchi, A., Butler, J. L:, Falkoff, R. J. M. and Fauci, A. S. (1984). Human B cell activation, proliferation and differentiation. Immunol. Rev., 78, 75–96

    Google Scholar 

  3. Soothill, J. F., Hayward, A. R. and Wood, C. B. S. (eds.) (1983). Pediatric Immunology(Oxford, London, Edinburgh, Boston, Carlton [Australia]: Blackwell Scientific Publications).

    Google Scholar 

  4. Delespesse, G., Sarfati, M., Lang, G. and Sehon, A. H. (1983). Prenatal and neonatal synthesis of IgE. In Monographs in Allergy, Vol. 18, pp. 83–95. ( Basel: Karger )

    PubMed  CAS  Google Scholar 

  5. Lawton, A. R. and Cooper, M. D. (1979). B cell ontogeny: immunoglobulin genes and their expression. Pediatrics, 64 (suppl.), 750–7

    PubMed  CAS  Google Scholar 

  6. Hay, F. C., Hull, M. G. R. and Torrigiani, G. (1971). The transfer of human IgG subclasses from mother to fetus. Clin. Exp. Immunol., 9, 355–8

    PubMed  CAS  Google Scholar 

  7. Wang, A. C., Faulk, W. P., Stuckey, M. A. and Fudenberg, H. H. (1970). Chemical differences of adult, fetal and hypogammaglobulinemic IgG immunoglobulins. Immuno- chemistry, 7, 703–8

    CAS  Google Scholar 

  8. Morrell, A., Skvaril, F., van Loghem, E. and Kleemola, M. (1971). Human IgG subclasses in maternal and fetal serum. Vox Sang., 21, 481–92

    Article  Google Scholar 

  9. Gitlin, D., Kumate, J., Urrusti, J. and Morales, C. (1964). The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. J. Clin. Invest. 43, 1938–51

    Article  PubMed  CAS  Google Scholar 

  10. Hobbs, J. R. and Davis J. A. (1967, Apr. 8). Serum G-globulin levels and gestational age in premature babies. Lancet, 1, 757–9

    CAS  Google Scholar 

  11. Chandra, R. K. (1976). Levels of IgG subclasses, IgA, IgM, and tetanus antitoxin in paired maternal and foetal sera; findings in healthy pregnancy and placental insufficiency. In Hemmings, W. A. (ed.) Maternofoetal Transmission of Immunoglobulins, pp. 77–90. ( London: Cambridge University Press )

    Google Scholar 

  12. Papadatos, C., Papaevangelou, G. J., Alexiou, D. and Mendris, J. (1970). Serum immunoglobulin G levels in small-for-dates newborn babies. Arch. Dis. Child., 45, 570–2

    Article  PubMed  CAS  Google Scholar 

  13. Von Muralt, G. (1985). Premature infants: replacement therapy with IV IgG in the perinatal period. Presented at The International Clinical Symposium on the Recognition and Management of Immunodeficient Disorders, April 17–19, Palm Springs, California

    Google Scholar 

  14. Givner, L. B., Edwards, M. S., Anderson, D. C. and Baker, C. J. (1985). Immune globulin for intravenous use: enhancement of in vitro opsonophagocytic activity of neonatal serum. J. Infect. Dis., 151, 217–20

    Article  PubMed  CAS  Google Scholar 

  15. Cederqvist, L. L., Ewool, L. C., Bonsnes, R. W. and Litwin, S. D. (1978). Detectability and pattern of immunoglobulins in normal amniotic fluid throughout gestation. Am. J. Ohstet. Gynecol., 130, 220–4

    CAS  Google Scholar 

  16. Grybos, M. (1984). G, A and M immunoglobulin levels in parturient’s blood serum, umbilical blood of their neonates and the amniotic fluid in physiological deliveries. Arch. Immunol. Ther. Exp., 32, 127–34

    CAS  Google Scholar 

  17. Loke, Y. W. (1978). Immunology and Immunopathology of the Foetal-Maternal Interaction. (Amsterdam Elsevier-North-Holland BiomedicalPress)

    Google Scholar 

  18. Singer, A., Hobel, C. and Heiner, D. C. (1974). Immunoglobulins in the amniotic fluid and fetus. Pediatr. Res., 8, 419

    Google Scholar 

  19. Singer, A. D., Hobel, C. J. and Heiner, D. C. (1974 Feb.). Evidence for secretory IgA and IgE in utero. J. Allergy Clin. Immunol., 53, 94

    Google Scholar 

  20. Cantuaria, A. A. and Jones, A. L. (1975, April). Immunoglobulin M in human amniotic fluid and its possible association with neural tube malformations. Br. J. Obstet. Gynaecol., 82, 262–4

    Article  PubMed  CAS  Google Scholar 

  21. Gill, T. J. Ill, Repetti, C. F., Metlay, L. A., Rabin, B. S., Taylor, F. H., Thompson, D. S. and Cortese, A. L. (1983). Transplacental immunization of the human fetus to tetanus by immunization of the mother. J. Clin. Invest. 72, 987–96

    Article  PubMed  Google Scholar 

  22. Allansmith, M., McClellan, B. H., Butterworth, M. and Maloney, J. R. (1968). The development of immunoglobulin levels in man. J. Pediatr., 72, 276–90

    Article  PubMed  CAS  Google Scholar 

  23. Morell, A., Skvaril, F., Hitzig, W. H., and Barandun, S. (1972). IgG subclasses: Development of the serum concentrations in ‘normal’ infants and children. J. Pediatr., 80, 960–4

    Article  PubMed  CAS  Google Scholar 

  24. Morrell, A., Terry, W. D., and Waldmann, T. A. (1970). Metabolic properties of IgG subclasses in man. J. Clin. Invest., 49, 673–80

    Article  Google Scholar 

  25. Schur, P. H., Rosen, F. and Norman, M. E. (1979). Immunoglobulin subclasses in normal children. Pediatr. Res., 13, 181–3

    Article  PubMed  CAS  Google Scholar 

  26. Oxelius, V-A. (1979). IgG subclass levels in infancy and childhood. Acta Paediatr. Scand., 68, 23–7

    Article  PubMed  CAS  Google Scholar 

  27. Zegers, B. J. M., Van der Giessen, M., Reerink-Brongers, E. E. and Stoop, J. W. (1980). The serum IgG subclass levels in healthy infants of 13–62 weeks of age. Clin. Chim. Acta, 101, 265–9

    Article  PubMed  CAS  Google Scholar 

  28. Van der Giessen, M., Rossouw, E., Veen, T. A.-Van, Loghem, E. V., Zegers, B. J. M. and Sander, P. C. (1975). Quantification of IgG subclasses in sera of normal adults and healthy children between 4 and 12 years of age. Clin. Exp. Immunol., 21, 501–9

    PubMed  Google Scholar 

  29. Johansson, S. G. O. and Berg, T. (1967). Immunoglobulin levels in healthy children. Acta Paediatr. Scand., 56, 572–9

    Article  PubMed  CAS  Google Scholar 

  30. Bousquet, J., Menardo, J-L. and Michel, F-B. (1984). Predictive capacity of cord blood IgE for the development of allergy in infancy and childhood. Ann. Allergy, 53, 692–5

    PubMed  CAS  Google Scholar 

  31. Berg, T. and Johansson, S. G. O. (1969). Immunoglobulin levels during childhood, with special regard to IgE. Acta Paediatr. Scand, 58, 513–24

    Article  PubMed  CAS  Google Scholar 

  32. Allansmith, M., McClellan, B. H., Butterworth, M. and Maloney, J. R. (1968). The development of immunoglobulin levels in man. J. Pediatr., 72, 276–90

    Article  PubMed  CAS  Google Scholar 

  33. Gerrard, J. W., Heiner, D. C., Chiew, G. K., Mink, J. T. and Myers, A. (1981). IgD levels in white and Metis communities in Saskatchewan. Ann. Allergy. 46, 321–4

    PubMed  CAS  Google Scholar 

  34. Kjellman, N.-I. M. (1976). Predictive value of high IgE levels in children. Acta Paediatr. Scand., 65, 465–71

    Article  PubMed  CAS  Google Scholar 

  35. Gerrard, J. W., Geddes, C. A., Reggin, P. L., Gerrard, C. D., Phil, B. and Horne, S. (1976). Serum IgE levels in white and Metis communities in Saskatchewan. Ann. Allergy, 37, 91–100

    PubMed  CAS  Google Scholar 

  36. Turner, K. J., Rosman, D. L. and O’Mahony, J. (1974). Prevalence and familial association of atopic disease and its relationship to serum IgE levels in 1061 school children and their families. Int. Arch. Allergy, 47, 650–64

    Article  PubMed  CAS  Google Scholar 

  37. Grundbacher, F. J. and Massie, F. S. (1985). Levels of immunoglobulin G, M, A, and E at various ages in allergic and nonallergic black and white individuals. J. Allergy Clin. Immunol., 75, 651–8

    CAS  Google Scholar 

  38. Wittig, H. J., Belloit, J., DeFillippi, I. and Royal, G. (1980). Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease. J. Allergy Clin. Immunol., 66, 305–13

    CAS  Google Scholar 

  39. South, M. A. and Alford, C. A., Jr. (1980). The immunology of chronic intrauterine infections. In Stiehm, E. R. and Fulginiti, V. (eds.) Immunologic Disorders in the Infant and Child, 2nd Edn., pp. 702–14. ( Philadelphia: W. B. Saunders )

    Google Scholar 

  40. Silverstein, A. (1972). Fetal immune responses in congenital infection. N. Engl. J. Med., 286, 1413–14

    Article  PubMed  CAS  Google Scholar 

  41. Stiehm, E. R., Ammann, A. J. and Cherry, J. D. (1966). Elevated cord macroglobulins in the diagnosis of intrauterine infections. N. Engl. J. Med., 275, 971–7

    Article  PubMed  CAS  Google Scholar 

  42. Alford, C. A., Jr., Wu, L. Y. F., Blanco, A. and Lawton, A. R. (1974). Developmental humoral immunity and congenital infections in man. In The Immune System and Infectious Diseases. 4th International Convocation of Immunology, pp. 42–58, Buffalo, NY. (Basel: Karger )

    Google Scholar 

  43. Alford, C. A., Schaefer, J., Blankenship, W. J., Straumfjord, J. V. and Cassady, G. (1967). A correlative immunologic, microbiologic and clinical approach to the diagnosis of acute and chronic infections in newborn infants. N. Engl. J. Med., 277, 437–49

    Article  PubMed  CAS  Google Scholar 

  44. Mason, E. O., South, M. A. and Montgomery, J. R. (1976) Cord serum IgA in congenital cytomegalovirus infection. J. Pediatr., 89, 945–6

    Article  PubMed  Google Scholar 

  45. Baker, C. J. and Kasper, D. L. (1976). Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection. N. Engl. J. Med. 294, 753–6

    Article  PubMed  CAS  Google Scholar 

  46. Baker, C. J., Edwards, M. S. and Kasper, D. L. (1981). Role of antibody to native type III polysaccharide of group B Streptococcus in infant infection. Pediatrics, 68, 544–9

    PubMed  CAS  Google Scholar 

  47. Oxelius, V.-A., Linden, V., Christensen, K.. K. and Christensen, P. (1983). Deficiency of IgG subclasses in mothers of infants with group B streptococcal septicemia. Int. Archs. Allergy Appl. Immun., 72, 249–52

    Article  CAS  Google Scholar 

  48. Marodi, L., Leigh, P. C. J., Braat, A., Daha, M. R. and Furth, R. van (1985). Opsonic activity of cord blood sera against various species of microorganism. Pediatr. Res., 19, 433–6

    Article  PubMed  CAS  Google Scholar 

  49. Hanson, L. A. and Brandtzaeg, P. (1980). The mucosal defense system. In Stiehm, E. R. and Fulginiti, V. A. (eds.) Immunologic Disorders in Infants and Children, 2nd Edn., pp. Oxelius, V-A. (1979). IgG subclass levels in infancy and childhood. Acta Paediatr. Scand.,137–64. ( Philadelphia: W. B. Saunders )

    Google Scholar 

  50. Keller, M. A., Heiner, D. C., Kidd, R. M. and Myers, A. A. (1983). Local production of IgG4 in human colostrum. J. Immunol., 130, 1654–7

    PubMed  CAS  Google Scholar 

  51. Ogra, P. L. (1979). Ontogeny of the local immune system. Pediatrics, 64 (Suppl.), 765–74

    PubMed  CAS  Google Scholar 

  52. Fulginiti, V. and Sieber, O., Jr. (1980). Immune mechanisms in infectious diseases. In Stiehm, E. R. and Fulginiti, V. (eds.) Immunologic Disorders in Infants and Children, pp. 687–701. ( Philadelphia: W. B. Saunders )

    Google Scholar 

  53. Griffiths, P. D., Berney, S. L, Argent, S. and Heath, R. B. (1982). Antibody against viruses in maternal and cord sera: specific antibody is concentrated on the fetal side of the circulation. J. Hyg., 89, 303–10

    Article  CAS  Google Scholar 

  54. Gotlieb-Stematsky, T., Meron, L, Modar, M., Sayar, Y., Leventon-Kriss, S., Fogel, A., Gurewitz, R. and Insler, V. (1983). Viral antibodies in maternal and cord sera. Med. Microbiol. Immunol. 172, 67–74

    Article  PubMed  CAS  Google Scholar 

  55. Johnston, R. B., Jr., Anderson, P., Rosen, F. S. and Smith, D. H. (1973). Characterization of human antibody to polyribophosphate, the capsular antigen of Hemophilus influenzae, type B. Clin. Immunol Immunopathol, 1, 234–40

    Article  PubMed  CAS  Google Scholar 

  56. Peltola, H., Kayhty, H., Sivonen, A. and Makela, P. H. (1977). Haemophilus influenzae type b capsular polysaccharide vaccine in children: a double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland. Pediatrics, 60, 730–7

    PubMed  CAS  Google Scholar 

  57. Heiner, D. C., Myers, A. and Beck, C. S. (1983). Deficiency of IgG4: a disorder associated with frequent infections and bronchiectasis that may be familial. Clin. Rev. Allerg. 1, 259–66

    CAS  Google Scholar 

  58. Beck, C. S. and Heiner, D. C. (1981). Selective immunoglobulin G4 deficiency and recurrent infections of the respiratory tract. Am. Rev. Respir. Dis., 124, 94–6

    PubMed  CAS  Google Scholar 

  59. Perelmutter, L. (1983). IgG4 and the immune system. Clin. Rev. Allerg., 1, 267–287

    CAS  Google Scholar 

  60. Heiner, D. C. (1984). Significance of immunoglobulin G subclasses. Am. J. Med., 76, 1–6

    Article  PubMed  CAS  Google Scholar 

  61. Bjorkander, J., Bake, B., Oxelius, V-A. and Hanson, L. A. (1985). Impaired lung function in patients with IgA deficiency and low levels of IgG2 or IgG3. N. Engl. J. Med., 313, 720–4

    Article  PubMed  CAS  Google Scholar 

  62. Oxelius, V-A., Laurell, A.-B., Lindquist, B., Golebiowska, H., Axelsson, U., Bjorkander, J. and Hanson, L. A. (1981). IgG subclasses in selective IgA deficiency. N. Engl. J. Med., 304, 1476–7

    Article  PubMed  CAS  Google Scholar 

  63. Ammann, A. J. and Hong, R. (1980). Disorders of the IgA system. In Stiehm, E. R. and Fulginiti, V. (eds.) Immunologic Disorders in Infants and Children, 2nd Edn., p. 263. ( Philadelphia: W. B. Saunders )

    Google Scholar 

  64. Ochs, H. D. and Wedgwood, R. J. (1980). Disorders of the B-cell system. In Stiehm, E. R. and Fulginiti, V. (eds.) Immunologic Disorders in Infants and Children, 2nd Edn., pp. 254 ( Philadelphia: W. B. Saunders )

    Google Scholar 

  65. Schanfield, M. S. (1981). Antibody-mediated perinatal diseases. Clin. Lab. Med., 1, 239–63

    PubMed  CAS  Google Scholar 

  66. Grundbacher, F. J. (1964). Changes in the human A antigen of erythrocytes with the individual’s age. Nature, 204, 192–4

    Article  PubMed  CAS  Google Scholar 

  67. Dufour, D. R. and Monoghan, W. P. (1980). ABO hemolytic disease of the newborn: a retrospective analysis of 254 cases. Am. J. Clin. Pathol., 73, 369–73

    PubMed  CAS  Google Scholar 

  68. Gupte, S. C. and Bhatia, H. M. (1980). Increased incidence of hemolytic disease of the newborn caused by ABO incompatibility when tetanus toxoid is given during pregnancy. •Vox Sang., 38, 22–8

    Article  PubMed  CAS  Google Scholar 

  69. Huntley, C, C., Costas, M. C. and Lyerly, A. (1965). Visceral larva migrans syndrome- clinical characteristics and immunologic studies in 51 patients. Pediatrics, 36, 523–36

    PubMed  CAS  Google Scholar 

  70. Heiner, D. C. and Levy, S. V. (1956). Visceral larva migrans: report of the syndrome in 3 siblings. N. Engl. J. Med., 254, 629

    Article  PubMed  CAS  Google Scholar 

  71. Shacks, S. J., Heiner, D. C., Bahna, S. L. and Horowitz, C. A. (1985). Increased serum IgG4 levels in acute Epstein-Barr viral mononucleosis. Ann. Allergy, 54, 284–8

    PubMed  CAS  Google Scholar 

  72. Bahna, S. L., Heiner, D. C. and Horowitz, C. A. (1984). Sequential changes of the five immunoglobulin classes and other responses in infectious mononucleosis. Int. Arch. Allergy Appl. Immunol., 74, 1–8

    Article  PubMed  CAS  Google Scholar 

  73. Bahna, S. L., Horwitz, C. and Heiner, D. C. (1978) IgE in cytomegalovirus mononucle mycoplasma infections with recurrence of wheezing in the asthmatic child. J. Allergy Clin. Immunol., 61, p. 177

    Article  Google Scholar 

  74. Berkovich, S., Millian, S. J. and Snyder, R. D. (1970). The association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child. Ann. Allergy 28, 43–9

    PubMed  CAS  Google Scholar 

  75. Melish, M. E. (1982). Kawasaki syndrome (the mucocutaneous lymph node syndrome). Pediatr. Ann., 11, 255–68

    PubMed  CAS  Google Scholar 

  76. Kusakawa, S., Ajugwo, R., Lee, W. Y., Tateno, K. and Heiner, D. C. (1976). Immunoglobulins in the mucocutaneous lymph node syndrome (MCLS). J. Allergy Clin. Immunol., 57, 243

    Google Scholar 

  77. Mason, W. H., Jordan, S. C, Sakai, R., Takahashi, M. and Bernstein, B. (1985). Circulating immune complexes in Kawasaki syndrome. Pediatr. infect. Dis., 4, 48–51

    Article  PubMed  CAS  Google Scholar 

  78. Furuse, A. and Matsuda, I. (1983). Circulating immune complex in the mucocutaneous lymph node syndrome. Eur. J. Pediatr., 141, 50 — 1

    Article  PubMed  CAS  Google Scholar 

  79. Furusho, K., Nakano, H., Shinomiya, K., Tamura, T., Manabe, Y., Kawarano, M., Baba, K., Kamiya, T., Kiyosawa, N., Hayashidera, T., Hirose, O., Yokoyama, T., Baba, K. and Mori, C. (1984). High-dose intravenous gammaglobulin for Kawasaki disease. Lancet, 2, 1055–8

    Article  PubMed  CAS  Google Scholar 

  80. Rogers, M. F. (1985). AIDS in children: a review of the clinical, epidemiologic and public health aspects. Pediatr. Infect. Dis., 4, 230–6

    Article  PubMed  CAS  Google Scholar 

  81. Rubinstein, A., Sicklick, M., Bernstein, L., Mayers, M., Lee, H. and Hollander, M. (1985). The spectrum of AIDS in infants. Lack of evidence for intrafamilial spread. Pediatr. Res., 18, 264A, No. 1009

    Google Scholar 

  82. Bernstein, L. J., Ochs, H. D., Wedgwood, R. J. and Rubinstein, A. (1985). Defective humoral immunity in pediatric acquired immune deficiency syndrome. J. Pediatr., 107, 352–7

    Article  PubMed  CAS  Google Scholar 

  83. Church, J. A., Lewis, J. and Spotkov, J. M. (1984). IgG subclass deficiencies in children with suspected AIDS. Lancet, 1, 279

    Article  PubMed  CAS  Google Scholar 

  84. Rubinstein, A., Sicklick, M., Bernstein, L., Silverman, B., Novick, B., Charytan, M. and Krieger, B. Z. (1985). Treatment of AIDS with intravenous gammaglobulin. Pediatr. Res., 18,264A, No. 1010

    Google Scholar 

  85. Pahwa, S. (1985). Children with AIDS. Presented at The International Clinical Symposium on the Recognition and Management of Immunodeficient Disorders, April 17–19, Palm Springs, California

    Google Scholar 

  86. Kaufman, H. S. and Frick, O. L. (1976). The development of allergy in infants of allergic parents: a prospective study concerning the role of heredity. Ann. Allergy, 37, 410–15

    PubMed  CAS  Google Scholar 

  87. Bahna, S. L. (1985). Care of the pregnant patient and her baby. Consultant, 75–89

    Google Scholar 

  88. Soothill, J. F., Stokes, C. R., Turner, M. W., Norman, A. P. and Taylor, B. (1976). Predisposing factors and the development of reaginic allergy in infancy. Clin. Allergy, 6, 305–19

    Article  PubMed  CAS  Google Scholar 

  89. Juto, P. (1980). Elevated serum IgE in T cell-deficient infants fed cow’s milk. J. Allergy Clin. Immunol., 66, 402–7

    Article  PubMed  CAS  Google Scholar 

  90. Bjorksten, B. (1984). Atopic allergy in relation to cell-mediated immunity. Clin. Rev. Allergy, 2, 95–106

    PubMed  CAS  Google Scholar 

  91. Dannaeus, A., Johansson, S. G. O. and Foucard, T. (1978). Clinical and immunological aspects of food allergy in childhood. Acta Paediatr. Scand., 67, 497–504

    Article  PubMed  CAS  Google Scholar 

  92. Croner, S., Kjellman, N-I. M., Eriksson, B. and Roth, A. (1982). IgE screening in 1701 newborn infants and the development of atopic disease during infancy. Arch. Dis. Child., 57, 364–8

    Article  PubMed  CAS  Google Scholar 

  93. Hamburger, R. N., Lenoir, M., Groshong, T. E., Miller, J. R., Wallace, W. and Orgel, H. A. (1974). Development of IgE and allergy during the first year of life: Preliminary data. J. Allergy Clin. Immunol., 53, 94

    Google Scholar 

  94. Capron, A., Dessaint, J. P. and Capron, M. (1980). Immunoregulation of parasite infections. J. Allergy Clin. Immunol., 66, 91–6

    Article  PubMed  CAS  Google Scholar 

  95. Soothill, J. F. (1984). Prevention of food allergic disease. Ann. Allergy, 53, 689–91

    PubMed  CAS  Google Scholar 

  96. Bellanti, J. A. (1984). Prevention of food allergies. Ann. Allergy, 53, 683–8

    PubMed  CAS  Google Scholar 

  97. Johnstone, D. E. and Dutton, A. M. (1966). Dietary prophylaxis of allergic disease in children. N. Engl. J. Med., 274, 715–19

    Article  PubMed  CAS  Google Scholar 

  98. Metzger, J. W., Turner, E. and Patterson, R. (1978). The safety of immunotherapy during pregnancy. J. Allergy Clin. Immunol., 61, 268–72

    Article  PubMed  CAS  Google Scholar 

  99. Uchida, T., Yui, T., Umezu, H. and Kariyone, S. (1984). Prolongation of platelet survival in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin. Thromb. Haemostas (Stuttgart), 51, 65–6

    CAS  Google Scholar 

  100. Fehr, J., Hofmann, V. and Kappeler, U. (1982). Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin. N. Engl. J. Med., 306, 1254–8

    Article  PubMed  CAS  Google Scholar 

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Schoettler, J., Heiner, D.C. (1986). Physiology and Pathology of Immunoglobulins in the Fetus and Child. In: French, M.A.H. (eds) Immunoglobulins in Health and Disease. Immunology and Medicine Series, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4169-4_7

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