Methodologic Issues in Investigations of Drug Abuse in Pregnancy
Studies of drug abuse in pregnancy pose no problems different from those in other types of medical investigations; however, they are characterized by a specific subset of analytic and interpretive problems. Foremost among these are vague hypotheses and study designs, difficulties in finding appropriate controls, small sample sizes, and loss of patients to follow-up. These problems will be discussed and guidelines presented on how to avoid them or to minimize their impact. These guidelines should be helpful to those planning and implementing research strategies, as well as to those who must apply the conclusions of the research of others in caring for their patients or formulating public policy.
KeywordsNull Hypothesis Confounding Variable METHODOLOGIC Issue Maternal Health Abnormal Outcome
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