Skip to main content
SpringerLink
Log in

The Secretion and Absorption of Fetal Lung Liquid

  • Chapter
Physiology of the Fetal and Neonatal Lung

Abstract

At the birth of a mammal dramatic changes must occur if the liquid-filled lungs of the fetus are to be transformed into an air-filled organ capable of supporting gas exchange. The aim of this paper is to examine some of the physiological mechanisms which bring about this metamorphosis, in particular those concerned with ion transport across the pulmonary epithelium.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Preyer, W. (1885). In Fernam, L. (ed.) Specielle Physiologie des Embryos. ( Leipzig: Th. Grieker’s Verlag )

    Google Scholar 

  2. Potter, E. L. and Bohlender, G. P. (1941). Intrauterine respiration in relation to development of the foetal lung. Am. J. Obstet. Gynecol., 42, 14–22

    Google Scholar 

  3. Jost, A. and Policard, A. (1948). Contribution experimentale a l’etude du development prenatal du poumon chez le lapin. Arch. Anat. Microsc., 37, 323–32

    Google Scholar 

  4. Adams, F. H., Moss, A. J. and Fagan, L. (1963). The tracheal fluid of the foetal lamb. Biol. Neonat., 5, 151–8

    Article  PubMed  CAS  Google Scholar 

  5. Adamson, T. M., Boyd, R. D. H., Piatt, H. S. and Strang, L. B. (1969). Composition of alveolar liquid in the foetal lamb. J. Physiol., 204, 159–68

    PubMed  CAS  Google Scholar 

  6. Olver, R. E. and Strang, L. B. (1974). Ion fluxes across the pulmonary epithelium and the secretion of lung liquid in the foetal lamb. J. Physiol., 241, 327–57

    PubMed  CAS  Google Scholar 

  7. Normand, I. C. S., Olver, R. E., Reynolds, E. O. R., Strang, L. B. and Welch, K. (1971). Permeability of lung capillaries and alveoli to non-electrolytes in the foetal lamb. J. Physiol., 219, 303–30

    PubMed  CAS  Google Scholar 

  8. Olver, R. E., Schneeberger, E. E. and Walters, D. V. (1981). Epithelial solute permeabil–ity, ion transport and tight junction morphology in the developing lung of the fetal lamb. J. Physiol, 315, 395–412

    PubMed  CAS  Google Scholar 

  9. Claude, P. and Goodenough, D. A. (1973). Fracture faces of zonulae occludentes from ‘tight’ and ‘leaky’ epithelium. J. Cell. Biol., 58, 390–400

    Article  PubMed  CAS  Google Scholar 

  10. Olver, R. E., Ramsden, C. A., Strang, L. B. and Walters, D. V. (1986). The role of amiloride blockable sodium transport in adrenaline induced lung liquid reabsorption in the fetal lamb. J. Physiol., 376, 321–40

    PubMed  CAS  Google Scholar 

  11. Alcorn, D., Adamson, T. M., Lambert, T. F., Maloney, J. E., Ritchie, B. C. and Robinson, P. M. (1977). Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung. J. Anat. London, 123, 649–60

    CAS  Google Scholar 

  12. Fewell, J. E., Hislop, A. A., Kitterman, J. A. and Johnson, P. (1983). Effect of tracheostomy on lung development in fetal lambs. J. Appl. Physiol., 55, 1103–8

    PubMed  CAS  Google Scholar 

  13. Liggins, G. C., Campos, G. A., Vilos, G. A., Kitterman, J. A., Lee, C. C. and Clements, J. A. (1981). The effect of bilateral thoracoplasty on lung development in fetal sheep. J. Dev. Physiol., 3, 275–82

    PubMed  CAS  Google Scholar 

  14. Brown, M. J., Olver, R. E., Ramsden, C. A., Strang, L. B. and Walters, D. V. (1983). Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J. Physiol., 344, 137–52

    PubMed  CAS  Google Scholar 

  15. Walters, D. V. and Olver, R. E. (1978). The role of catecholamines in lung liquid absorption at birth. Ped. Res., 12, 239–42

    Article  CAS  Google Scholar 

  16. Enhorning, G., Chamberlain, D., Contreras, C., Burgoyne, R. and Robertson, B. (1977). Isoxuprine–induced release of pulmonary surfactant in the rabbit fetus. Am. J. Obstet. Gynecol., 129, 197–202

    PubMed  CAS  Google Scholar 

  17. Bland, R. D., McMillan, D. D. and Bressack, M. A. (1979). Labor decreases lung water content of newborn rabbits. Am. J. Obstet. Gynecol., 134, 364–7

    Google Scholar 

  18. Lagercrantz, H., Bistoletti, P. and Nylund, L. (1981). Sympathoadrenal activity in the foetus during delivery and at birth. In Stern, L. et al. (eds.) Intensive Care of the Newborn, pp. 1–12. ( New York: Mason Press )

    Google Scholar 

  19. Buhler, H. V., Da Prada, M., Haefely, W. and Picotti, G. B. (1978). Plasma adrenaline, noradrenaline and dopamine in man and different animal species. J. Physiol., 276, 311–20

    PubMed  CAS  Google Scholar 

  20. Matthay, M. A., Landolt, C. C. and Staub, N. C. (1982). Differential liquid and protein clearance from the alveoli of anesthetized sheep. J. Appl. Physiol., 53, 96–104

    PubMed  CAS  Google Scholar 

  21. Legris, G. J., Will, P. C. and Hopfer, V. (1982). Human and baboon bronchial sodium absorption: implications for airway fluid movement and the mucociliary clearance mechanism. Chest, 81, (Suppl.), 9S–11S

    Google Scholar 

  22. Egan, E. A., Olver, R. E. and Strang, L. B. (1975). Changes in non–electrolyte permeability of alveoli and the absorption of lung liquid at the start of breathing in the lamb. J. Physiol., 244, 161–79

    PubMed  CAS  Google Scholar 

  23. Cassin, S., Dawes, G. S. and Ross, B. B. (1964). Pulmonary blood flow and vascular resistance in immature foetal lambs. J. Physiol., 171, 80–9

    PubMed  CAS  Google Scholar 

  24. Edmonds, C. J. (1981). Amiloride sensitivity of the trans–epithelial electrical potential of sodium and potassium transport in the rat distal colon, in vivo. J. Physiol., 313, 547–59

    PubMed  CAS  Google Scholar 

  25. Olver, R. E., Schneeburger, E. E. and Walters, D. V. (1981). Epithelial solute permeabi–lity, ion transport and tight junction morphology in the developing lung of the lamb. J. Physiol. 315, 395–412

    PubMed  CAS  Google Scholar 

  26. Claude, P. and Goodenough, D. A. (1973). Fracture faces of zonulae occludentes from ‘tight’and ‘leaky’ epithelium. J. Cell Biol., 58, 390–400

    Article  PubMed  CAS  Google Scholar 

  27. Adamson, T. M., Boyd, R. D. H., Piatt, H. S. and Strang, L. B. (1969). Composition of alveolar liquid in the foetal lamb. J. Physiol., 204, 159–68

    PubMed  CAS  Google Scholar 

  28. Mortola, J. P., Fisher, J. T., Smith, J. B., Fox, G. S., Weeks, S. and Willis, D. (1982). Onset of respiration in infants delivered by caesarean section. J. Appl. Physiol 52, 716–24

    PubMed  CAS  Google Scholar 

  29. Fisher, J. T., Mortola, J. P., Smith, J. B., Fox, G. S. and Weeks, S. (1982). Respiration in newborns. Development of the control of breathing. Am. Rev. Resp. Dis., 125, 650–7

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. D. V. Walters
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. A. Ramsden
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Paediatrics, University College Hospital Medical School, The Rayne Institute, London, UK

    D. V. Walters  & L. B. Strang  & 

  2. Clinic des Maladies de l’Enfance, Université de Liege, Belgium

    F. Geubelle

Rights and permissions

Reprints and permissions

Copyright information

© 1987 MTP Press Limited

About this chapter

Cite this chapter

Walters, D.V., Ramsden, C.A. (1987). The Secretion and Absorption of Fetal Lung Liquid. In: Walters, D.V., Strang, L.B., Geubelle, F. (eds) Physiology of the Fetal and Neonatal Lung. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4155-7_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4155-7_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8344-7

  • Online ISBN: 978-94-009-4155-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation