Abstract
Neu drug delivery systems are characterized by rate-control1ed drug release in vivo, which is predictable on the basis of the in vitro release profile. They are capable of producing relatively constant drug concentrations in the body for long periods of time and this may be desirable for many drugs. This is discussed in terms of pharmacokinetic/pharmacodynamic relationships. The potential advantages of rate-control1ed drug delivery systems are reviewed, and their use as research tools in pharmacology and toxicology (for example osmotic pumps) is described. The extent of application in animal health care is very much dependent on economic benefit; some examples are given of rumen delivery systems and injectable or implantable systems. The major areas of application include therapy with antibiotic and parasitic agents, the long-term delivery of anthelmintic and/or antibacterial agents for growth promotion, the delivery of hormones to achieve accelerated growth or oestrus synchronization and the long-term administration of trace nutrients.
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References
Algar, B., Irlam, P., Knott, P., Telfer, S. and Zervas, G. (1985). The use of soluble glasses to provide a controlled supply of trace elements to ruminant animals. In: Peppas, N.A. and Haluska, (eds). Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials, pp. 190–191. Lincolnshire: The Controlled Release Society Inc.
Borgsteed, F.H.M. (1983). The effects of morantel sustained release bolus system on calves grazing a highly contaminated pasture in The Netherlands. Vet. Parasitol. 12: 251–260.
Breimer, D.D., De Leede, L.G.J, and De Boer, A.G. New drug delivery systems as tools in clinical pharmacology. In: Lemberger, L. and Reidenberg, M.M. (eds). Proceedings of the 2nd World Conference on Clinical Pharmacology and Therapeutics, pp.431–443. Washington: American Society for Pharmacology and Experimental Therapeutics.
Breimer, D.D., De Leede, L.G.J, and De Boer, A.G. Rate-controlled rectal drug delivery. In: Prescott, L.F. and Nimmo, W.S. (eds). Rate Control in Drug Therapy, pp.54–64. Edinburgh: Churchill Livingstone.
Byford, R.L., River, J.L. and Hair, J.A. (1981). A sustained release oxytetracycline bolus for ruminants. Bovine.Pract. 15: 91–94.
Cardinal, J. (1985). Controlled drug delivery: veterinary app1ications. J. Controlled Release 2: 393–403.
Chien, Y.W. (1982). Novel Drug Delivery Systems. New York: Marcel Dekker.
Chien, Y.W. (1985). Implants and depot formulations: subcutaneous controlled oestrus synchronization. In: Prescott, L.F. and Nimmo, W.S. (eds). Rate Control in Drug Therapy, pp. 90–102. Edinburgh: Churchill Livingstone.
Chien, Y.W. and Kabadi, M.B. (1985). Intravaginal controlled oestrus synchronisation. (II) Intravaginal delivery of flurogestone acetate, in vitro — in vivo correlation and clinical efficacy. In: Peppas, N.A. and Haluska, R.J. (eds). Proceedings of the 12th International Symposium on Controlled Release of Bioactive Materials, pp. 353–354. Lincolnshire: The Controlled Release Society Inc.
Davis, S.S., Hardy, J.G., Taylor, M.J., Stockwell, A., Whalley, D.R. and Wilson, C.G. (1984). The in vivo evaluation of an osmotic device (OSMET) using gamma scintigraphy. J. Pharm. Pharmacol. 16: 740–742.
Goldman, P. (1982). Rate-controlled drug delivery. New Engl. J. Med. 307: 286–290.
Heilman, K. (1982). Therapeutische Systeme. Konzept und Realisation programmierter Arzneiverabreichung, 2nd ed. Stuttgart: Enke Verlag.
Jones, R.M. (1983). Therapeutic and prophylactic efficacy of morantel when administered directly into the rumen of cattle on a continuous basis. Vet. Parasitol. 12: 223–232.
Lambert, S.B. and Davis, G.V. (1983). The effects of Compudose, Ralgro and Synovex-S implants on performance of finishing yearling steers. J. Animal Sci. 57 (Suppl. I), 399
Nau, H. (1983). The role of delivery systems in toxicology and drug development. Pharm. Intern. 4: 228–231.
Prost, H., Supperer, R., Jones, R.M., Lockwood, P.W. and Bliss, D.H. (1983). Morantel sustained release bolus: a new approach for the control of Trichostrongy1osis in Austrian cattle. Vet. Parasitol. 12: 239–250.
River, J.L., Byford, R.L., Stratton, L.G. and Hair, J.A. (1982). Influence of density and location on degradation of sustained release boluses given to cattle. Am. J. Vet. Res. 43: 2023–2030.
Simpson, B.E. (1983). Sustained release capsule for ruminants. U.S. Patent 4.416. 659.
Struyker Boudier, H.A.J. (1982). Rate-controlled drug delivery: pharmacological, therapeutic and industrial perspective. Trends Pharmacol. Sci. 3: 162–164.
Theeuwes, F. and Yum, S.I. (1976). Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid formulations. Ann. Biomed. Eng. 4: 343–353.
Urquhart, J. (1981). Performance requirement for control1ed-release dosage forms: therapeutic and pharmacological perspective. In: Urquhart, J. (ed.). Control 1ed-Release Pharmaceutical s, pp. 1–48. Washington: American Pharmaceutical Association.
Urquhart, J., Fara, J. and Willis, K.L. (1984). Rate-controlled delivery systems in drug and hormone research. Ann. Rev. Pharmacol. Toxicol. 24: 199–236.
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Breimer, D.D. (1986). Potential of new drug delivery systems in veterinary medicine. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_8
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DOI: https://doi.org/10.1007/978-94-009-4153-3_8
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