Abstract
Butorphanol is a synthetic opiate of the cyclorphan series which possesses both narcotic agonist and antagonist properties. The drug has been characterized pharmacologically and clinically in humans as an analgesic and as a component of balanced anaesthesia, and in dogs it has been used as an antitussive agent.
In order to determine the clinical utility of butorphanol as an analgesic in horses, a clinical and Pharmacological evaluation of the agent was undertaken in horses. Analgesic activity was demonstrable in a dose- dependent manner in horses, the intravenous administration of 0.1 mg/kg providing a justifiable clinical dosage. In double-blind clinical studies in horses presenting with acute abdominal pain, the analgesic effectiveness of butorphanol at a dosage of 0.1 mg/kg was confirmed.
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© 1986 MTP Press Limited
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Gingerich, D.A., Rourke, J.E., Strom, P.W., Gordon, L.L., Kalpravidh, M. (1986). Analgesic activity of butorphanol in horses: dosage titration and clinical studies. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_4
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DOI: https://doi.org/10.1007/978-94-009-4153-3_4
Publisher Name: Springer, Dordrecht
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Online ISBN: 978-94-009-4153-3
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