Abstract
The usefulness of a unified pharmacokinetic model for the chronic testing of drug residues is described. The model was very suitable for the disposition and metabolism rate of methylch1oroform (MC) in humans, rats and mice, at various exposure levels and with two different routes of administration. The physiological parameters fed into the model take account of old and young animals. The model could provide more reliable estimations of health hazards for the chemicals in our environment.
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References
Agin. G.L. and Blau. G.E. (1982). Application of DACSL (Dow Advanced Continuous Simulation Language) to the design and application of chemical reactor systems. Amer. Inst. Chem. Eng. Symp. Ser. No. 214, 78: 108–118.
Andersen. M.E.. Gargas. M.L. and Ramsey, J.C. (1984). Inhalation pharmacokinetics: evaluating systemic extraction, total in vivo metabolism, and the time course of enzyme induction for inhaled styrene in rats based on arterial blood: inhaled air concentration ratios 1. Toxicol. Appl. Pharmacol. 73: 175–187.
Anderson. M.W., Hoel, D.G. and Kaplan, N.L. (1980). A general scheme for the incorporation of pharmacokinetics in low-dose risk estimation for chemical carcinogenesis: Example - Vinyl Chloride. Toxicol. Appl. Pharmacol. 55: 154.
Caster, W.O., Poncelet, J., Simon, A.B. and Armstrong, W.D. (1956). Tissue weights of the rat. I. Normal values determined by dissection and chemical methods. Proc. Soc. Exp. Biol. Ned. 91: 122–126.
Davis, N.R. and Mapleson, W.W. (1981). Structure and quantification of a physiological model of the distribution of injected agents and inhaled anaesthetics. Br. Journal Anaesth. 53: 399–405.
Gehring, P.J. (1968). Hepatotoxic potency of various chlorinated hydrocarbon vapors relative to their narcotic and lethal potencies in mice. Toxicol. Appl. Pharmacol. 13: 287–298.
Gehring. P.J. and Blau, G.E. (1977). Mechanisms of carcinogenesis dose response. J. Env. Path. Toxicol. 1: 163–179.
International Commission on Radiation Protection (1975). Report of the task group on reference man. W.S. Snyder et al. (eds). ICRP Publication 23. New York: Pergamon Press.
Nolan, R.J., Freshour, N.L., Rick, D.L., McCarty, L.P. and Saunders, J.H. (1984). Kinetics and metabolism of inhaled methyl chloroform (1,1,1-trichloroethane) in male volunteers. Fund. Appl. Toxicol. 4: 654–662.
Ramsey. J.C. and Andersen, M.E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. APPI. Pharmacol. 73: 159–175.
Reitz, R.H., Schumann, A.M., Osborne, D.W. and Nolan, R.J. Pharmacokinetics of 1.1.1-trichloroethane (MC) in humans, rats and mice after inhalation or drinking water administration. The Toxicologist 5: 110.
Schumann, A.M., Fox, T.R. and Watanabe, P.G. (1982). [14C]methyl chloroform (1.1.1-trichloroethane): Pharmacokinetics in rats and mice following inhalation exposure. Toxicol. APPI. Pharmacol. 62: 390–401.
Schumann, A.M., Fox, T.R. and Watanabe, P.G. (1982). A comparison of the fate of inhaled methyl chloroform (1.1.1-trichloroethane) following single or repeated exposure in rats and mice. Fundam. Appl. Toxicol. 2:27–32.
Watanabe, P.G., Zemple, J.A., Pegg, D.Y. and Gehring, P.J. (1978). Hepatic macromolecular binding following exposure to vinyl chloride. Toxicol. Appl. Pharmacol. 44: 571–579.
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Verschuuren, H.G., Reitz, R.H. (1986). The use of pharmacokinetics in chronic toxicity testing. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_20
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DOI: https://doi.org/10.1007/978-94-009-4153-3_20
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8343-0
Online ISBN: 978-94-009-4153-3
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