Abstract
In the safety evaluation of animal drugs both the target animal species and man have to be considered. In the case of feed additives the environment is a third factor. The value of the target animal species in safety evaluation can be increased considerably if more advantage is taken of information obtained either directly or indirectly from target animal studies. In particular, this applies to studies of drug pharmacokinetics and metabolism and to toxic effects in the target animal. The ultimate goals have to be to obtain more relevant data for a well-balanced risk assessment and concomitantly aim at a reduction of the total testing programme.
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© 1986 MTP Press Limited
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De Roij, T.A.J.M. (1986). The target animal species in drug toxicity studies: an evaluation of its usefulness and limitations. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_19
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DOI: https://doi.org/10.1007/978-94-009-4153-3_19
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8343-0
Online ISBN: 978-94-009-4153-3
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