Abstract
In species-dependent pharmacokinetics there are three main variables: the structure of the drug, the mechanism and route of metabolism. and renal excretion. When the drug is administered orally, the structure and characteristics of the gastrointestinal tract are an additional factor which may dominate the overall pharmacokinetic behavior. Sulphonamides are metabolized by acetylation-deacetylation reactions and by hydroxylation. Hydroxylation is possible at different positions in the N1-substituent group. The ratio between acetylation and hydroxylation depends on the structure of the sulphonamide and the species. Renal function, as expressed by inulin or creatinine clearance, is almost independent of the species and related to the body weight. The renal excretion mechanisms of sulphonamides and their metabolites are governed by the molecular structure and kidney architecture, but not by animal species.
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Vree, T.B., Nouws, J.F.M., Hekster, Y.A. (1986). Comparative pharmacokinetic studies of sulphonamides. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_17
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DOI: https://doi.org/10.1007/978-94-009-4153-3_17
Publisher Name: Springer, Dordrecht
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