Abstract
The histamine H2-receptor antagonist ranitidine was tested for its effect on the rabbit small intestine. Preparations of isolated segments of duodenum, jejunum and ileum of adult animals were used. Ranitidine possessed a significant stimulant action on these preparations, the action being strongest on the duodenum and weakest on the ileum. The maximum response to ranitidine was about 62% of the maximum response to acetylcholine. Ranitidine produced a dose-dependent potentiation of acetylcholine- induced contractions and the stimulant action of ranitidine was prevented by atropine. These findings suggest that ranitidine’s stimulant action is associated with the cholinergic system and it occurs in descending degree of intensity from the duodenum to the ileum.
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Kounenis, G., Koutsoviti-Papadopoulou, M., Elezoglou, V. (1986). Cholinergic-like effect of the H2-receptor antagonist ranitidine on the rabbit small intestine. In: Van Miert, A.S.J.P.A.M., Bogaert, M.G., Debackere, M. (eds) Comparative Veterinary Pharmacology, Toxicology and Theraphy. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4153-3_14
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DOI: https://doi.org/10.1007/978-94-009-4153-3_14
Publisher Name: Springer, Dordrecht
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