Abstract
In a first clinical study (Gonsette et al. 1977), a short-term (2–3 weeks) intensive immunosuppression was induced by intravenous injection of high doses of cyclophosphamide (CY) in multiple sclerosis (MS) patients with a remitting-progressive form. After a follow-up for 2-6 years, it appeared that a marked reduction of the annual relapse rate (ARR) as well as a stabilization of neurological and functional disability were observed respectively in 70 and 62% of the patients. The same beneficial effect of intensive CY immunosuppression on the progressive form of the disease has been observed by Hommes et al. (1980) and Hauser et al. (1983).
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References
Brinkman, C.J.J., Nillesen, W.M., and Hommes, O.R., 1984. The effect of cyclophosphamide on T lymphocytes and T lymphocyte subsets in patients with chronic progressive multiple sclerosis. Acta Neurol. Scand., 69: 90–96.
Feringa, E.R., Davis, S.W., Vahlsing, H.L., and Shuer, L.M., 1978. Fink- Heimer/Nauta demonstration of regenerating axons in the rat spinal cord. Arch. Neurol., 35: 522–526.
Gonsette, R.E., Demonty, L., and Delmotte, P., 1977. Intensive immunosuppression with cyclophosphamide in multiple sclerosis. Follow-up of 110 patients for 2–6 years. J. Neurol., 214: 173–181.
Hauser, S.L., Dawson, D.M., Lehrich, J.R., Beal, M.F., Kevy, S.V., Propper, R.D., Mills, J.A., and Weiner, H.L., 1983. Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. New Engl. J. Med., 308: 173–180.
Hommes, O.R., Lamers, K.J.B., and Reekers, P., 1980. Effect of intensive immunosuppression on the course of chronic progressive multiple sclerosis. J. Neurol., 223: 177–190.
Lublin, F.D., 1984. Immunomodulation of relapsing experimental allergic encephalomyelitis. Neurol., 34: 1615–1617.
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© 1986 ECSC, EEC, EAEC, Brussels and Luxembourg
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Gonsette, R.E., Demonty, L. (1986). Immunosuppression with Cyclophosphamide in Multiple Sclerosis Patients. In: Hommes, O.R. (eds) Multiple Sclerosis Research in Europe. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4143-4_6
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DOI: https://doi.org/10.1007/978-94-009-4143-4_6
Publisher Name: Springer, Dordrecht
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