Abstract
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system (CNS), induced by active sensiti¬zation of susceptible animals with CNS tissue. The basic lesion in the brain of EAE animals is the perivenous inflammatory reaction, which appears to be essentially mediated by a cellular immune reaction directed against myelin basic protein (MBP), a component of myelin sheaths (Ben Nun et al., 1981). The clinical and pathohistological expression of the disease, however, can to a large extent be modified by other, including humoral immune reactions (Paterson, 1982; Schwerer et al., 1984). This modification seems to be partially responsible for the extensive diversi¬ty between different EAE models (Lassmann, 1983).
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© 1986 ECSC, EEC, EAEC, Brussels and Luxembourg
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Lassmann, H., Vass, K. (1986). The Spectrum of Experimental Allergic Encephalomyelitis. In: Hommes, O.R. (eds) Multiple Sclerosis Research in Europe. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4143-4_15
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DOI: https://doi.org/10.1007/978-94-009-4143-4_15
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