Abstract
Clinical studies in Multiple Sclerosis (MS) have a long tradition, the first clinical description being published over a century ago. But even earlier than this, a patient with MS, Augustus d’Este, recorded his symptoms in a detailed diary (Firth 1948). D’Este’s handwriting gives more accurate account of his state of health than any medical description could: In 1822 it was extremely legible, but by 1848, shortly before his death, ataxia had deteriorated his penmanship considerably.
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© 1986 ECSC, EEC, EAEC, Brussels and Luxembourg
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Poser, S. (1986). Clinical Studies in Multiple Sclerosis. In: Hommes, O.R. (eds) Multiple Sclerosis Research in Europe. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4143-4_1
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DOI: https://doi.org/10.1007/978-94-009-4143-4_1
Publisher Name: Springer, Dordrecht
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