Abstract
The toxicology of food has always been a science divided between two laudable objectives. The first and most ancient objective is the essentially practical one of defining what is safe to eat. It seems likely that even primitive man learned to define good foods and bad foods by observation of animals, and by associating taste with adverse responses such as bitterness or nausea. This aspect of toxicology finds its counterpart today in the regulatory control of the quality of foodstuffs using more advanced methods. The second objective is to understand the mechanism whereby a chemical adversely affects biological systems. The purpose of this is as much to understand about the functioning of the biological system as to define the toxic mechanism. Safety considerations have increasingly overshadowed, and currently almost eclipsed, the investigations of the mechanisms of production of any toxic effects produced by food.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cohen, AJ (1979). Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man. Fd Cosmet Toxicol, 17, 277–89
Grasso, P and Gray, TJB (1977). Long-term studies on chemically induced liver enlargement in the rat. III. Structure and behaviour of the hepatic nodular lesions induced by Ponceau MX. Toxicology, 7, 327–47
Lintas, C, de Matthaeis, MC and Merli, F (1979). Determination of Benzol[a]pyrene in smoked, cooked and toasted food products. Fd Cosmet Toxicol, 17, 325–8
Sharman, IM (1985). Hypercarotenaemia. Br Med J, 290, 95–6
IARC Monographs (1983). The evaluation of the carcinogenic risk of chemicals to humans. Vol. 32. Polynuclear Aromatic Compounds, Part 1, Chemical, Environmental and Experimental Data. (Lyon: World Health Organization )
Ames, BN, McCann, J and Yamasuki, E (1975). Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Res, 31, 347–64
Ashby, J, de Serres, FJ, Draper, M, Ishidate, M Jr, Margolin, BH, Matter, BE and Shelby, MD (eds) (1985). Evaluation of short-term tests for carcinogens. Report of the International Programme on Chemical Safety’s Collaborative Study on in vitro Assays Progress in Mutation Res, Vol 5, pp. 117–74( Amsterdam: Elsevier Science Publishers )
Sobels, FH (1985). Editorial. A comprehensive exercise in comparative mutagenesis with exciting outcome - or - How good are mutation assays in predicting carcinogens? Mutation Res, 147, 1–4
Egger, J, Carter, CM, Graham, PJ, Gumley, D and Soothill, JF (1985) Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet, 1, 540–5
Tryphonas, H and Trites, R (1984), Diet and hyperactivity. BNF Nutr Bull, 9, 24–31
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 MTP Press Limited
About this chapter
Cite this chapter
Conning, D.M., Butterworth, K.R. (1986). Foods and Food Additives. In: Worden, A.N., Parke, D.V., Marks, J. (eds) The Future of Predictive Safety Evaluation. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4139-7_8
Download citation
DOI: https://doi.org/10.1007/978-94-009-4139-7_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8336-2
Online ISBN: 978-94-009-4139-7
eBook Packages: Springer Book Archive