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The Use of Human Biological Measurements for Safety Evaluation in the Chemical Industry

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The Future of Predictive Safety Evaluation

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Abstract

Although man has been exposed to naturally occurring poisons since the beginning of his existence, it is only in the past 80 years that there has been a dramatic increase in the number of synthetic chemicals, a few of which have subsequently been shown to cause health problems following human exposure. However, health in this country is better than in past times and the expectation of life in this chemical age is longer than ever before[l]. There is no evidence of mass harm to the population from new substances[2,3]. In the chemical industry, past history has shown that health effects have usually resulted from specific exposures; for example: bladder cancer from exposure to aromatic amines, fibrotic lung disease from exposure to silica dust, mesothelioma from asbestos, occupational asthma from exposure to platinum salts and more recently angiosarcoma of the liver from exposure to vinyl chloride monomer. As well as in the industrial situation, man is exposed to chemicals in pharmaceutical preparations, domestic products, food additives, pesticide residues and from accidental contamination of the environment.

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Authors
  1. W. Howe
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  2. M. D. Stonard
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  3. B. H. Woollen
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Editor information

Editors and Affiliations

  1. Cantab Group, Cambridge, England

    A. N. Worden

  2. Department of Biochemistry, University of Surrey, Guildford, England

    D. V. Parke

  3. Girton College, Cambridge, England

    J. Marks (Director of Medical Studies) (Director of Medical Studies)

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© 1986 MTP Press Limited

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Howe, W., Stonard, M.D., Woollen, B.H. (1986). The Use of Human Biological Measurements for Safety Evaluation in the Chemical Industry. In: Worden, A.N., Parke, D.V., Marks, J. (eds) The Future of Predictive Safety Evaluation. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4139-7_5

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  • DOI: https://doi.org/10.1007/978-94-009-4139-7_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8336-2

  • Online ISBN: 978-94-009-4139-7

  • eBook Packages: Springer Book Archive

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