Abstract
A correlation between CE50, the metal-ion concentration which reduces the cloning efficiency of Chinese hamster ovary (CHO) cells by 50%, and IC50, the metal-ion concentration that produces an inhibition of calmodulin activity of 50%, is reported for 10 divalent metal ions. It is thus suggested that IC50 might be used as a predictor of metal-ion toxicity in CHO cells. Arguments are presented to support the extrapolation of these results to other pollutants and to other biological species.
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© 1987 D. Reidel Publishing Company
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Williams, M.W., Turner, J.E., Hsie, A.W. (1987). Calmodulin Inhibition: A Possible Predictor of Metal-Ion Toxicity. In: Kaiser, K.L.E. (eds) QSAR in Environmental Toxicology - II. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3937-0_31
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DOI: https://doi.org/10.1007/978-94-009-3937-0_31
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8246-4
Online ISBN: 978-94-009-3937-0
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