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QSAR in Environmental Toxicology - II pp 281–293Cite as

The Use of Luminescent Bacteria in the Study of Structure/Toxicity Relationships for Trichothecenes

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Abstract

A feasibility study on the potential use of a luminescent bacteria bioassay in the toxicity screening of trichothecenes is presented. The toxic effects of four 12,13-epoxytrichothecenes to bioluminescent bacteria were determined for the first time using the Microtox™ Toxicity Analyzer (TM: Trademark of Microbics Corporation, Carlsbad, California). The influence of test temperature and exposure time on the toxic effect of trichothecenes to the luminescent bacteria are discussed. The toxicities measured are compared with toxic effects determined using other bioassays. Potential relationships between the toxicities found and variations in the chemical structure of these compounds are considered.

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Authors and Affiliations

  1. Toxicology Research Centre, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada

    Juan M. Ribo

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  1. Juan M. Ribo
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Editors and Affiliations

  1. National Water Research Institute, Canada Centre for Inland Waters, Burlington, Ontario, Canada

    Klaus L. E. Kaiser

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© 1987 D. Reidel Publishing Company

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Ribo, J.M. (1987). The Use of Luminescent Bacteria in the Study of Structure/Toxicity Relationships for Trichothecenes. In: Kaiser, K.L.E. (eds) QSAR in Environmental Toxicology - II. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3937-0_22

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  • DOI: https://doi.org/10.1007/978-94-009-3937-0_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8246-4

  • Online ISBN: 978-94-009-3937-0

  • eBook Packages: Springer Book Archive

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