Abstract
A hazard assessment scheme was developed and applied to predict potential harm to aquatic biota of nearly 500 organic compounds detected by GC/MS in Great Lakes fish. The frequency of occurrence and estimated concentrations of compounds found in lake trout (Salvelinus namaycush) and walleyes (Stizostedion v. vitreum) were compared with available manufacturing and discharge information. Bioconcentration potential of the compounds was estimated from available data or from quantitative structure-activity relationship (QSAR) calculations. We also measured the acute toxicity to Daphnia pulex (48-hr EC50s) of 35 representative compounds and compared the results with acute toxicity values generated by QSAR. The QSAR-derived toxicities for several chemicals underestimated the actual acute toxicity by one or more orders of magnitude. A multiple regression of log EC50 on log water solubility and molecular volume is a useful predictive model.
Contribution 664, National Fisheries Center - Great Lakes, Ann Arbor, Michigan 48105, U.S.A.
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References
Baumann, P.C. 1984. Cancer in wild freshwater fish populations with emphasis on the Great Lakes. J. Great Lakes Res. 10: 251–253.
Hesselberg, R.J. and Seelye, J.G. 1982. Identification of organic compounds in Great Lakes fishes by gas chromatography/mass spectrometry: 1977. Administrative Report No. 82–1. Great Lakes Fishery Laboratory, Ann Arbor, Michigan.
Mac, M.J., Edsall, C.C. and Seelye, J.G. 1985. Survival of lake trout eggs and fry reared in water from the upper Great Lakes. J. Great Lakes Res. 11: 520–529.
National Fisheries Center - Great Lakes. 1986. Progress in Fishery Research 1984–1985. U.S. Fish and Wildlife Service, National Fisheries Center - Great Lakes, Ann Arbor, Michigan, 67 p.
Passino, D.R.M., Hesselberg, R.J. and Willford, W.A. 1987. Preliminary identification and hazard ranking of 476 organic compounds in Great Lakes fishes. J. Great Lakes Res. (in press).
Perry, Cynthia M. 1985. The Toxicological Effects of Six Heterocyclic Nitrogen Compounds on Daphnia pulex. M.S. Thesis, Eastern Michigan University, Ypsilanti, Michigan.
SAS Institute Inc. 1985. SAS Users Guide: Basics, Version 5 Edition. SAS Institute Inc., Cary, North Carolina.
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© 1987 D. Reidel Publishing Company
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Passino, D.R.M., Smith, S.B. (1987). Quantitative Structure-Activity Relationships (QSAR) and Toxicity Data in Hazard Assessment. In: Kaiser, K.L.E. (eds) QSAR in Environmental Toxicology - II. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3937-0_20
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DOI: https://doi.org/10.1007/978-94-009-3937-0_20
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8246-4
Online ISBN: 978-94-009-3937-0
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