Abstract
For organic chemicals causing toxicity primarily by narcosis, Fergusonian theory suggests that, at the site of toxic action, toxicant concentration should be relatively constant for the biological response in question. It can be shown, employing existing acute and chronic toxicity QSARs and bioconcentration log Kow relationships, that this is true. Equipotency does appear to exist, at least as a first approximation, and estimated whole body toxicant concentrations are presented for some organic chemicals.
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© 1987 D. Reidel Publishing Company, Dordrecht, Holland
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McCarty, L.S. (1987). Relationship between Toxicity and Bioconcentration for Some Organic Chemicals. I. Examination of the Relationship. In: Kaiser, K.L.E. (eds) QSAR in Environmental Toxicology - II. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3937-0_16
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DOI: https://doi.org/10.1007/978-94-009-3937-0_16
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