Abstract
In specifying new drug administration modes, one must keep in mind the merits of conventional routes. Indeed, we shall show herein that a modern administration device aids the scheduling of cyclosporine (Cs) according to a conventional treatment mode. Cs is a hydrophobic 11-amino-acid cyclic polypeptide (1), produced by two soil fungi, soluble in lipids or organic solvents, that was found to have immunosuppressive properties by Borel et al. (2,3) at Sandoz Ltd. (Basel, Switzerland). Studies in experimental animals by Calne et al. (4) and other investigators (5) showed that Cs could prevent or greatly delay the onset of organ allograft rejection. The mechanism of action of Cs is not well understood. The drug depresses humoral and cellular immunity, with a preferential and reversible action against T lymphocytes (6,7). These effects are not accompanied by the bone marrow depression that is frequent during treatment with azathioprine. Among its side effects, recent clinical trials have shown nephrotoxicity and hepatotoxicity at the usual therapeutic doses in transplanted patients (8–10). Our studies on the rat and the dog underline the importance of chronopharmacology and chronotherapy and how modern instrumentation can optimize the schedule of Cs administration.
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Cavallini, M., Halberg, F., Cornélissen, G., Sutherland, D.E.R. (1987). Modern drug administration devices for the chronobiologic optimization of conventional treatment modes. In: Scheving, L.E., Halberg, F., Ehret, C.F. (eds) Chronobiotechnology and Chronobiological Engineering. NATO ASI Series, vol 120. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3547-1_2
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DOI: https://doi.org/10.1007/978-94-009-3547-1_2
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