Abstract
Iodine radionuclides have been used for many years for the simple and rapid labelling of biological substances, particularly antibodies. Amongst the thirty-two known isotopes of iodine, iodine-123 and iodine-131 are the most routinely used because of their physical properties (Figure 1).
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References
Fraker P J, Speck J C, Protein and cell membrane iodina- tions with a sparingly soluble chloroamide Biochem Biophys Res Commun 1978; 80: 849.
Bolter A E, Hunter W M, The labelling of proteins to high specific radioactivities by conjugation to a I-125-con- taining acylating agent Biochem J 1973; 133: 529.
Richardson A P, Mountford P J, Baird A C, Heyderman E, Richardson T C, Coakley A J, An improved Iodogen method of labelling antibodies with I-123 Nucl Med Commun 1986; 7: 355.
Mather S J, Radioiodinated Monoclonal Antibodies: a Critical Review Appl Radiat Isot 1986; 37: 727.
Andrew S M, Pimm M V, Perkins A C, Baldwin R W, Compara¬tive imaging and biodistribution studies with an anti-CEA monoclonal antibody and its F(ab’)2 and Fab fragments in mice with colon carcinoma xenografts Eur J Nucl Med 1986; 12: 168.
Steinsträsser A, Schwarz A, Kuhlmann L. Monoclonal Anti¬bodies: Optimizing of Labelling Procedures by Quality- control Methods (Poster) 3. Eur Symp Radiopharmacy and Radi opharmaceuti cals, Elsmore 1987.
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Bremer, K.H., Schwarz, A. (1987). Labelling Methods with Radioactive Iodine. In: Kristensen, K., Nørbygaard, E. (eds) Safety and Efficacy of Radiopharmaceuticals 1987. Developments in Nuclear Medicine, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3375-0_4
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DOI: https://doi.org/10.1007/978-94-009-3375-0_4
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8016-3
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