Abstract
It has been questioned whether radioactive labelling of human cells is safe enough to be recommended for clinical use because of very high radiation doses delivered to the labelled cells. Commonly used activities of In-111 or Tc-99m for clinical studies may deliver some 10 to 100 Gy to the cells carrying the intracel1ular label, mainly from selfirradiation due to Auger electrons (1,2,3,4). Organ and whole body doses, however, are of the same order of magnitude as commonly accepted in diagnostic studies (e.g. 3,5,6,7). The very high cellular doses have been documented from theoretical calculations as well as measurements of functional disturbances, decreased cell viability and finally chromosome aberrations in lymphocytes (8). Although there is no clear relation between chromosome damage and oncogenesis the main concern has been the possible transformation and oncogenetic potential of these heavily irradiated lymphocytes, of which a small fraction may survive and proliferate.
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Dige-Petersen, H. (1987). Safety Aspects of Human Use of Labelled Cells. In: Kristensen, K., Nørbygaard, E. (eds) Safety and Efficacy of Radiopharmaceuticals 1987. Developments in Nuclear Medicine, vol 14. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3375-0_13
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DOI: https://doi.org/10.1007/978-94-009-3375-0_13
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