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Nephrotoxicity in the experimental and clinical situation pp 167–188Cite as

Correlating Structural and Functional Changes in Nephrotoxic Renal Injury

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Part of the book series: Developments in Nephrology ((DINE,volume 19-20))

Abstract

The mammalian kidney is particularly susceptible to a variety of toxic agents. The fact that the kidneys receive approximately 20–25% of the cardiac output and yet make up only about 1% of the total body weight probably accounts for this susceptibility. As such, the structural integrity of the renal tubule is frequently compromised in response to ischaemic and toxic insults. Probably the most common lesion seen in experimental models of acute renal injury is necrosis of the proximal tubular epithelium. Prolonged renal ischaemia or direct exposure to a wide variety of toxins are the usual causes of acute tubular injury. The term acute renal failure has often been equated with acute tubular necrosis. While the interchangeable use of these two terms is reasonable for most experimental models where renal dysfunction is associated with a definitive lesion, the presence of underlying extensive tubular injury in clinical forms of acute renal failure is not prominent. Hence, the question of whether morphological injury precedes or contributes to the development of renal dysfunction remains controversial, at least in the clinical setting.

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Authors
  1. D. C. Dobyan
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  2. G. Eknoyan
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  3. R. E. Bulger
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Editor information

Editors and Affiliations

  1. The Robens Institute, University of Surrey, Guildford, Surrey, England

    P. H. Bach

  2. Biochemical Toxicology Section, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire, England

    E. A. Lock

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© 1987 Martinus Nijhoff Publishers

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Dobyan, D.C., Eknoyan, G., Bulger, R.E. (1987). Correlating Structural and Functional Changes in Nephrotoxic Renal Injury. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity in the experimental and clinical situation. Developments in Nephrology, vol 19-20. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3367-5_5

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  • DOI: https://doi.org/10.1007/978-94-009-3367-5_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8012-5

  • Online ISBN: 978-94-009-3367-5

  • eBook Packages: Springer Book Archive

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