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Metabolic Activation of Halogenated Chemicals and its Relevance to Nephrotoxicity

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Nephrotoxicity in the experimental and clinical situation

Part of the book series: Developments in Nephrology ((DINE,volume 19-20))

Abstract

A number of chlorine-, bromine- and fluorine-containing organic molecules cause nephrotoxicity in experimental animals and in some cases in man. Many of these chemicals are used as industrial solvents, chemical intermediates or pesticides, while others have had a more direct clinical application as anticancer chemotherapeutic agents or anaesthetics. Several reviews on the effect of these chemicals on the kidney are available1–5. This chapter will therefore not discuss all halogenated chemicals which produce renal necrosis, but instead will review selected examples of the types of mechanism(s) whereby halogenated chemicals can be activated by renal tissue and thereby cause toxicity.

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  1. The Robens Institute, University of Surrey, Guildford, Surrey, England

    P. H. Bach

  2. Biochemical Toxicology Section, Imperial Chemical Industries plc, Alderley Park, Macclesfield, Cheshire, England

    E. A. Lock

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Lock, E.A. (1987). Metabolic Activation of Halogenated Chemicals and its Relevance to Nephrotoxicity. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity in the experimental and clinical situation. Developments in Nephrology, vol 19-20. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3367-5_14

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