Skip to main content
SpringerLink
Log in

Survey of experimental data on fetal liver transplantation

  • Chapter
Fetal liver transplantation

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 18))

  • 49 Accesses

Summary

Fetal liver transplantation has been shown to induce hematogological and immunological reconstitution in irradiated rodents, dogs, horses and sheep. Engraftment and reconstitution without GvHD has been readily obtained using histocompatible donors. When mismatched fetal donors were used, a comparatively larger number of donor cells was required, in addition to pre-treatment of host with higher doses of irradiation or irradiation plus chemotherapy. Stem cell suspensions devoid of any T lymphocyte can be transplanted across major histocompatibility barrier without inducing overt GvHD. The transplanted animals become tolerant to both donor and host grafts.

Author for correspondence.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andreani M, De Biagi M, Centis F, Manna M, Agostinelli F, Filipetti A, Gaudenzi G, Muretto P, Grianti C, Sotti G, Rigon A, Lucarelli G (1985) Fetal liver transplantation in the mini-pig. In: Gale RP, Touraine JL, Lucarelli G (eds) Progress in Clinical and Biological Research: Fetal liver transplantation. New York: Alan R. Liss, Inc., p. 205.

    Google Scholar 

  2. Boersma WJA (1983) Prothymocytes in mouse fetal liver. Thymus 5: 419.

    PubMed  CAS  Google Scholar 

  3. Bortin MM, Saltzstein EC (1969) Graft-versus-host inhibition: Fetal liver and thymus cells to minimize secondary disease. Science 164: 316.

    Article  PubMed  CAS  Google Scholar 

  4. Bunch C, Wood WG, Kelly SJ (1985) Fetal hemopoietic-cell transplantation in sheep: An approach to the cellular control of hemoglobin switching. In Gale RP, Touraine JL, Lucarelli G (eds) Progress in Clinical and Biological Research: Fetal Liver Transplantation. New York: Alan R. Liss Inc., p. 219.

    Google Scholar 

  5. Champlin RE, Cain G, Stitzel KA, Gale RP (1987) Sustained recovery of hematopoiesis and immunity following transplantation of fetal liver cells in dogs. Thymus, this issue.

    Google Scholar 

  6. Crouch BG (1959) Transplantation of fetal hemopoietic tissues into irradiated mice and rats. In: Proc. Seventh Congress of the Eur. Soc. for Haematology, London, p. 973.

    Google Scholar 

  7. Fleischman RA, Cluster RP, Mintz B (1982) Totipotent hematopoietic stem cells: Normal self-renewal and differentiation after transplantation between mouse fetuses: Cell 30: 351.

    Article  PubMed  CAS  Google Scholar 

  8. Grebe SC, Streilen JW (1976) Graft-versus-host reactions: A review. Adv. Immunol. 22:119.

    Article  CAS  Google Scholar 

  9. Kelemen E, Gulya E, Szabo (Hatvan)(1980) Xenogeneic transfer of fetal liver- and adult bone marrow-derived hemopoietic cells in rodents. In: Lucarelli G, Fliedern TM, Gale RP (eds) Fetal liver transplantation. Amsterdam: Excerpta Medica, p. 168.

    Google Scholar 

  10. Korngold R, Sprent J (1982) Features of T-cells causing H-2 restricted lethal graft- versus-host disease across minor histocompatibility barrier. J. Exp. Med. 155: 182.

    Article  Google Scholar 

  11. Goodman JW, Wheeler HB (1968) Factors that modify poor growth of parental marrow cells in F1 hybrid mice. In: Dausset J, Hamburger J, Mathé G (eds) Advance in Transplantation. Copenhagen: Munskgaard, p. 427.

    Google Scholar 

  12. Goodman JW, Shinpock SG (1968) Influence of thymus cells on erythropoiesis of parental marrow in irradiated hybrid mice. Proc. Soc. Exp. Biol. Med. 129: 417.

    PubMed  CAS  Google Scholar 

  13. Lôwenberg B (1975) Fetal liver cell transplantation. Thesis. Erasmus University Rotterdam. Publication of the Radiobiological Institute of the Organization for Health Research TNO, Rijswijk ( ZH ), The Netherlands.

    Google Scholar 

  14. Mintz B (1985) Renewal and differentiation of totipotent hematopoietic stem cells of the mouse after transplantation into early fetuses. In: Gale RP, Touraine JL, Lucarelli G (eds) Progress in Clinical and Biological Research: Fetal Liver Transplantation. New York: Alan R. Liss, Inc., 193: 3.

    Google Scholar 

  15. O’Reilly R (1983) Allogeneic bone marrow transplantation: Current status and future directions. Blood 62: 941.

    PubMed  Google Scholar 

  16. Perryman LE (1980) Use of fetal tissues for immunoreconstitution in horses with severe combined immunodeficiency. In: Lucarelli G, Fliedner TM, Gale RP (eds) Fetal Liver Transplantation, Current Concepts and Future Directions. Amsterdam, Excerpta Medica, p. 183.

    Google Scholar 

  17. Priimmer O, Raghavarvachar A, Werner C, Calvo W, Carbonell F, Steinbach I, Fliedner TM (1985) Fetal liver transplantation in the dog. Transplantation 39: 349.

    Article  Google Scholar 

  18. Rabinowich H, Umiel T, Globerson A (1983) T cell progenitors in the mouse fetal liver. Transplantation 35: 40.

    Article  PubMed  CAS  Google Scholar 

  19. Schofield R (1970) A comparative study of the repopulating potential of grafts from various haemopoietic sources: CFU repopulation. Cell Tissue Kinet 3: 119.

    PubMed  CAS  Google Scholar 

  20. Thomas ED, Storb R, Clift RA et al (1975) Bone marrow transplantation. N. Engl. J. Med. 292: 832.

    Article  PubMed  CAS  Google Scholar 

  21. Thomas ED, Storb R, Clift RA et al (1975) Bone marrow transplantation. N. Engl. J. Med. 292: 895.

    Article  PubMed  CAS  Google Scholar 

  22. Touraine JL, Roncarolo MG, Royo C, Touraine F (1987) Fetal tissue transplantation, bone marrow transplantation and prospective gene therapy in severe immunodeficiencies and enzyme deficiencies: Thymus, this issue.

    Google Scholar 

  23. Touraine JL (1983) Bone marrow and fetal liver transplantation in immunodeficiencies and inborn errors of metabolism: Lack of significant restriction of T-cell function in long-term chimeras despite HLA-mismatch. Immunological Rev. 71: 103.

    Article  CAS  Google Scholar 

  24. UphofTDE (1958) Preclusion of secondary phase of irradiation syndrome by inoculation of fetal hematopoietic tissue following lethal total-body X-irradiation. J. Natl. Cancer Inst. 20: 625.

    Google Scholar 

  25. Zanjani ED, McGlave PB, Stamatoyannopoulos G (1980) Fetal to adult transplant in sheep: A model for study of hemoglobin switching. In: Lucarelli G, Fliedner TM, Gale RP (eds) Fetal Liver Transplantation. Current Concepts. Amsterdam: Excerpta Medica, p. 108.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Transplantation and Immunobiology Unit, Pavillon P, Hôpital Edouard Herriot, F-69437, Lyon Cédex 08, France

    C. Royo, J.-L. Touraine, P. Veyron & A. Aitouche

Authors
  1. C. Royo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J.-L. Touraine
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Veyron
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Aitouche
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hôpital Edouard Herriot, Lyon, France

    Jean-Louis Touraine

  2. Transplantation Biology Program, University of California, Los Angeles, USA

    Robert Peter Gale

  3. Institute Rotary, Cancer Hospital, New Delhi, India

    Vinod Kochupillai

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Royo, C., Touraine, JL., Veyron, P., Aitouche, A. (1987). Survey of experimental data on fetal liver transplantation. In: Touraine, JL., Gale, R.P., Kochupillai, V. (eds) Fetal liver transplantation. Developments in Hematology and Immunology, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3365-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-3365-1_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8011-8

  • Online ISBN: 978-94-009-3365-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation