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S-Adenosyl-L-Homocysteine Hydrolase as Target Enzyme for Antiviral Agents: Studies with Adenosine Kinase-Deficient Rat Cells

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Frontiers in Microbiology

Part of the book series: New Perspectives in Clinical Microbiology ((NPCM,volume 13))

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Abstract

During the last decade several adenosine analogues with potent anti-viral activities have been developed. Their mode of action mostly remains to be elucidated: they may be targeted at a number of enzymes including S-adenosylhomocysteine (SAH) hydrolase, adenosine kinase, adenosine deaminase, ribonucleotide reductase and DNA polymerase.

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References

  1. Shipman C Jr, Tong S-L, Smith SH, Katlama NB, Drach JC. Antimicrob. Agents Chemother. 24:947–949, 1983.

    PubMed  CAS  Google Scholar 

  2. Inaba M, Nagashima K, Tsukagoshi S, Sakurai Y. Cancer Res. 46:1063–1067, 1986.

    PubMed  CAS  Google Scholar 

  3. Chiang PK, Richards HH, Cantoni GL. Mol. Pharmacol. 13:939–947, 1977.

    PubMed  CAS  Google Scholar 

  4. De Clercq E, Cools M. Biochem. Biophys. Res. Commun. 129:306–311, 1985.

    Article  PubMed  Google Scholar 

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Cools, M., Drach, J.C., De Clercq, E. (1987). S-Adenosyl-L-Homocysteine Hydrolase as Target Enzyme for Antiviral Agents: Studies with Adenosine Kinase-Deficient Rat Cells. In: De Clercq, E. (eds) Frontiers in Microbiology. New Perspectives in Clinical Microbiology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3353-8_38

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  • DOI: https://doi.org/10.1007/978-94-009-3353-8_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8006-4

  • Online ISBN: 978-94-009-3353-8

  • eBook Packages: Springer Book Archive

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