Abstract
During the last decade several adenosine analogues with potent anti-viral activities have been developed. Their mode of action mostly remains to be elucidated: they may be targeted at a number of enzymes including S-adenosylhomocysteine (SAH) hydrolase, adenosine kinase, adenosine deaminase, ribonucleotide reductase and DNA polymerase.
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Shipman C Jr, Tong S-L, Smith SH, Katlama NB, Drach JC. Antimicrob. Agents Chemother. 24:947–949, 1983.
Inaba M, Nagashima K, Tsukagoshi S, Sakurai Y. Cancer Res. 46:1063–1067, 1986.
Chiang PK, Richards HH, Cantoni GL. Mol. Pharmacol. 13:939–947, 1977.
De Clercq E, Cools M. Biochem. Biophys. Res. Commun. 129:306–311, 1985.
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Cools, M., Drach, J.C., De Clercq, E. (1987). S-Adenosyl-L-Homocysteine Hydrolase as Target Enzyme for Antiviral Agents: Studies with Adenosine Kinase-Deficient Rat Cells. In: De Clercq, E. (eds) Frontiers in Microbiology. New Perspectives in Clinical Microbiology, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3353-8_38
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DOI: https://doi.org/10.1007/978-94-009-3353-8_38
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8006-4
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