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GFA and S 100 Proteins in Low Grade Astrocytomas

  • B. Lechevalier
  • F. Chapon
  • J. F. Viel
  • J. P. Houtteville
Chapter
  • 37 Downloads
Part of the Developments in Oncology book series (DION, volume 52)

Abstract

Two glia specific proteins have been identified by biochimists and immunologists: the glial fibrillary acidic (GFA) protein (2,3,10) and the S 100 protein (13,17,18,19).

Key words

Immunocytochemistry Histopathology Markers Differentiation Grading 

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References

  1. 1.
    Benda (P.) (1968): Protéine S-100 et tumeurs humaines. Rev. Neurol. 118, 368–372.PubMedGoogle Scholar
  2. 2.
    Bignami (A.), Eng (L.F.), Dahl (D.), Uyeda (C.T.) (1973): Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 43, 429–435.CrossRefGoogle Scholar
  3. 3.
    Bignami (A.), Dahl (D.) (1977): Specificity of the glial fibrillary acidic protein for astroglia. J. Histochem. Cytochem. 25, 466–469.PubMedCrossRefGoogle Scholar
  4. 4.
    Conley (F.K.)(1979): The immunocytochemical localization of GFA Protein in Experimental Murine CNS Tumors. Acta Neuropathol. (Berl.), 45, 9–16.CrossRefGoogle Scholar
  5. 5.
    Deck (J.H.), Eng (L.F.), Bigbee (J.) (1976): A preliminary study of glioma morphology using the peroxidase-antiperoxidase immunohistological method for glial fibrillary acidic protein. J. Neuropath. Exp. Neurol., 35, 362.CrossRefGoogle Scholar
  6. 6.
    Deck (J.H.), Eng (L.F.), Bigbee (J.), Woodcock (S.M.) (1978): The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. Acta Neuropathologica (Berl.), 42, 183–190.CrossRefGoogle Scholar
  7. 7.
    Delpech (B.), Delpech (A.), Vidard (M.N.), Girard (N.), Tayot (J.), Clement (J.C.), Creissard (P.) (1978): Glial fibrillary acidic protein in tumors of the nervous system. Br. J. Cancer 37, 33–40.PubMedCrossRefGoogle Scholar
  8. 8.
    Dohan (F.C.), Kornblith (P.L.), Wellum (G.R.), Pfeiffer (S.E.), Levine (L.) (1977): S-100 Protein and 2′, 3′ -Cyclic Nucleotide 3′-Phosphohydrolase in Human Brain Tumors. Acta Neuropathol. (Berl.) 40, 123–128.CrossRefGoogle Scholar
  9. 9.
    Duffy (P.E.), Graf (L.), Rapport (M.M.) (1977): Identification of glial fibrillary acidic protein by the immunoperoxidase method in human brain tumors. J. Neuropath. Exp. Neurol. 36, 645–652.PubMedCrossRefGoogle Scholar
  10. 10.
    Eng (L.F.), Vanderhaeghen (J.J.), Blgnami (A.), Gerstl (B.) (1971): An acidic protein isolated from fibrous astrocytes. Brain Res. 28, 351–354.PubMedCrossRefGoogle Scholar
  11. 11.
    Eng (L.F.), Rubinstein (L.) (1978): Contribution of immunohistochemistry to diagnostic problems of human cerebral tumors. J. Histochem. Cytochem. 26, 513–523.PubMedCrossRefGoogle Scholar
  12. 12.
    Haglid (K.G.), Stravrou (D.), Ronnback (L.), Carlisson (C.A.), Weidenbach (W.) (1973): The S-100 protein in water-soluble and pentanol-extractable forms in normal human brain and tumors of the human nervous system: A quantitative study. J. Neurol. Sci. 20, 103–111.PubMedCrossRefGoogle Scholar
  13. 13.
    Hyden (H.), Mcewen (N.) (1966): A glial protein specific for the nervous system. Proc. Nat. Acad. Sci. 55, 354–358.PubMedCrossRefGoogle Scholar
  14. 14.
    Jacque (C.M.), Kujas (M.), Poreau (A.), Raoul (M.), Collier (P.), Racadot (J.), Baumann (N.) (1979): GFA and S-100 Protein levels as an index for malignancy in human gliomas and neurinomas. J. Natl. Cancer Inst. 62, 479–483.PubMedGoogle Scholar
  15. 15.
    Kernohan (J.W.), Sayre (G.P.) (1952): Tumors of the central nervous system. Fascicule 35, Atlas of Tumor Pathology Washington: Armed Forces Institutes of Pathology (AFIP).Google Scholar
  16. 16.
    Maunoury (R.), Delpech (A.), Delpech (B.), Vldard (M.N.), Vedrenne (C.), Constans (J.P.), Hlllereau (J.) (1977): Localisation de la protéine gliofibrillaire (GFAP) par immunocytochimie dans les tumeurs cérébrales humaines. Neuro-Chirurgie 23, 173–185.PubMedGoogle Scholar
  17. 17.
    Moore (B.W.) (1965): A soluble protein characteristic of the nervous system. Biochemical and biophysical research communications 19, 739–744.PubMedCrossRefGoogle Scholar
  18. 18.
    Moore (B.W.) (1972): Chemistry and biology of two proteins S-100 and 14-3-2, specific to the nervous system. International review of Neurobiology 15, 215–225.PubMedCrossRefGoogle Scholar
  19. 19.
    Pfeiffer (S.E.), Herschman (H.R.), Lightbody (J.) and Sato (G.V.) (1970): Synthesis by a clonal line of rat glial cell of a protein unique to the nervous system. J. Cell. Physiol. 75, 329–339.PubMedCrossRefGoogle Scholar
  20. 20.
    Sternberger (L.A.) and Cuculis (J.J.) (1969): Method for enzymatic intensification of the immuno cytochemical reaction without use of labelled antibodies. J. Histochem. Cytochem. 17, 190.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • B. Lechevalier
    • 1
  • F. Chapon
    • 1
  • J. F. Viel
    • 2
  • J. P. Houtteville
    • 3
  1. 1.Laboratoire de neuropathologieC.H.U.CaenFrance
  2. 2.Laboratoire d’informatique médicale et d’épidémiologieC.H.U.CaenFrance
  3. 3.Service de neurochirurgieC.H.U.CaenFrance

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