Skip to main content

GFA and S 100 Proteins in Low Grade Astrocytomas

  • Chapter
Brain Oncology Biology, diagnosis and therapy

Part of the book series: Developments in Oncology ((DION,volume 52))

  • 48 Accesses

Abstract

Two glia specific proteins have been identified by biochimists and immunologists: the glial fibrillary acidic (GFA) protein (2,3,10) and the S 100 protein (13,17,18,19).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Benda (P.) (1968): Protéine S-100 et tumeurs humaines. Rev. Neurol. 118, 368–372.

    PubMed  CAS  Google Scholar 

  2. Bignami (A.), Eng (L.F.), Dahl (D.), Uyeda (C.T.) (1973): Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res. 43, 429–435.

    Article  Google Scholar 

  3. Bignami (A.), Dahl (D.) (1977): Specificity of the glial fibrillary acidic protein for astroglia. J. Histochem. Cytochem. 25, 466–469.

    Article  PubMed  CAS  Google Scholar 

  4. Conley (F.K.)(1979): The immunocytochemical localization of GFA Protein in Experimental Murine CNS Tumors. Acta Neuropathol. (Berl.), 45, 9–16.

    Article  CAS  Google Scholar 

  5. Deck (J.H.), Eng (L.F.), Bigbee (J.) (1976): A preliminary study of glioma morphology using the peroxidase-antiperoxidase immunohistological method for glial fibrillary acidic protein. J. Neuropath. Exp. Neurol., 35, 362.

    Article  Google Scholar 

  6. Deck (J.H.), Eng (L.F.), Bigbee (J.), Woodcock (S.M.) (1978): The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors. Acta Neuropathologica (Berl.), 42, 183–190.

    Article  CAS  Google Scholar 

  7. Delpech (B.), Delpech (A.), Vidard (M.N.), Girard (N.), Tayot (J.), Clement (J.C.), Creissard (P.) (1978): Glial fibrillary acidic protein in tumors of the nervous system. Br. J. Cancer 37, 33–40.

    Article  PubMed  CAS  Google Scholar 

  8. Dohan (F.C.), Kornblith (P.L.), Wellum (G.R.), Pfeiffer (S.E.), Levine (L.) (1977): S-100 Protein and 2′, 3′ -Cyclic Nucleotide 3′-Phosphohydrolase in Human Brain Tumors. Acta Neuropathol. (Berl.) 40, 123–128.

    Article  CAS  Google Scholar 

  9. Duffy (P.E.), Graf (L.), Rapport (M.M.) (1977): Identification of glial fibrillary acidic protein by the immunoperoxidase method in human brain tumors. J. Neuropath. Exp. Neurol. 36, 645–652.

    Article  PubMed  CAS  Google Scholar 

  10. Eng (L.F.), Vanderhaeghen (J.J.), Blgnami (A.), Gerstl (B.) (1971): An acidic protein isolated from fibrous astrocytes. Brain Res. 28, 351–354.

    Article  PubMed  CAS  Google Scholar 

  11. Eng (L.F.), Rubinstein (L.) (1978): Contribution of immunohistochemistry to diagnostic problems of human cerebral tumors. J. Histochem. Cytochem. 26, 513–523.

    Article  PubMed  CAS  Google Scholar 

  12. Haglid (K.G.), Stravrou (D.), Ronnback (L.), Carlisson (C.A.), Weidenbach (W.) (1973): The S-100 protein in water-soluble and pentanol-extractable forms in normal human brain and tumors of the human nervous system: A quantitative study. J. Neurol. Sci. 20, 103–111.

    Article  PubMed  CAS  Google Scholar 

  13. Hyden (H.), Mcewen (N.) (1966): A glial protein specific for the nervous system. Proc. Nat. Acad. Sci. 55, 354–358.

    Article  PubMed  CAS  Google Scholar 

  14. Jacque (C.M.), Kujas (M.), Poreau (A.), Raoul (M.), Collier (P.), Racadot (J.), Baumann (N.) (1979): GFA and S-100 Protein levels as an index for malignancy in human gliomas and neurinomas. J. Natl. Cancer Inst. 62, 479–483.

    PubMed  CAS  Google Scholar 

  15. Kernohan (J.W.), Sayre (G.P.) (1952): Tumors of the central nervous system. Fascicule 35, Atlas of Tumor Pathology Washington: Armed Forces Institutes of Pathology (AFIP).

    Google Scholar 

  16. Maunoury (R.), Delpech (A.), Delpech (B.), Vldard (M.N.), Vedrenne (C.), Constans (J.P.), Hlllereau (J.) (1977): Localisation de la protéine gliofibrillaire (GFAP) par immunocytochimie dans les tumeurs cérébrales humaines. Neuro-Chirurgie 23, 173–185.

    PubMed  CAS  Google Scholar 

  17. Moore (B.W.) (1965): A soluble protein characteristic of the nervous system. Biochemical and biophysical research communications 19, 739–744.

    Article  PubMed  CAS  Google Scholar 

  18. Moore (B.W.) (1972): Chemistry and biology of two proteins S-100 and 14-3-2, specific to the nervous system. International review of Neurobiology 15, 215–225.

    Article  PubMed  CAS  Google Scholar 

  19. Pfeiffer (S.E.), Herschman (H.R.), Lightbody (J.) and Sato (G.V.) (1970): Synthesis by a clonal line of rat glial cell of a protein unique to the nervous system. J. Cell. Physiol. 75, 329–339.

    Article  PubMed  CAS  Google Scholar 

  20. Sternberger (L.A.) and Cuculis (J.J.) (1969): Method for enzymatic intensification of the immuno cytochemical reaction without use of labelled antibodies. J. Histochem. Cytochem. 17, 190.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Lechevalier, B., Chapon, F., Viel, J.F., Houtteville, J.P. (1987). GFA and S 100 Proteins in Low Grade Astrocytomas. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-3347-7_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8003-3

  • Online ISBN: 978-94-009-3347-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics