Abstract
Intra-arterial infusion of BCNU provides a substantial advantage over intravenous administration for treatment of malignant gliomas (4, 6). The ocular complications, which reduce this modality of therapy (5), are avoided by selective supra ophthalmic carotid artery infusion (2,8).
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References
Blacklock (J.B.), Wright (D.C.), Derrick (R.L.), Blasberg (R.G.), Lutz (R.J.), Doppman (J.L.) and Oldfield (E.H.): Drug streaming during intra-arterial chemotherapy. J. Neurosurg. 64: 284–291 (1986).
Debrun (G.M.), Davis (K.R.) and Hochberg (F.H.). Superselective injection of BCNU through a latex calibrated-leak balloon. AJNR, 4: 399–400 (1983).
De Wys (W.D.) and Fowler (E.H.): Report of vasculitis and blindness after intracarotid injection of 1, 3-Bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in dogs. Cancer Chemother. Rep 57: 33–40 (1973).
Greenberg (H.S.), Ensminger (W.D.), Seeger (J.F.), Kindt (G.W.), Chandler (W.F.), Doan (K.) and Dakhil (S.R.): Intra-arterial chemotherapy for the treatment of malignant gliomas of the central nervous system: a preliminary report. Cancer Treat. Rep., 65: 803–810 (1981).
Greenberg (H.S.), Ensminger (W.D.), Chandler (W.F.), Layton (P.B.), Junck (L.), Knake (J.) and Vine (A.K.): Intra-arterial BCNU chemotherapy for treatment of malignant gliomas of the central nervous system. J. Neurosurg., 61: 423–429 (1984).
Hochberg (H.S.), Pruitt (A.A.), Beck (D.O.), Debrun (G.) and Davis (K.): The rationale and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma. J. Neurosurg., 63: 876–880 (1985).
Kapp (J.P.), Vance (R.), Parker (J.L.) and Smith (R.R.): Limitations of high dose intra-arterial, 1, 3-Bis (2-Chlorethyl)-1-nitrosourea (BCNU) chemotherapy for malignant gliomas. J. Neurosurg., 10: 715–719 (1982).
Kapp (J.P.), Ross (R.L.) and Tucker (E.M.): Supraophthalmic carotid infusion for brain-tumor chemotherapy. J. Neurosurg., 58: 616–618 (1983).
Layton (P.B.), Greenberg (H.S.), Stetson (P.L.), Ensminger (W.D.) and Gyves (J.W.). BCNU solubility and toxicity in the treatment of malignant astrocytomas. J. Neurosurg., 60: 1134–1137 (1984).
Lutz (R.J.), Dedrick (R.L.), Boretos (J.W.), Oldfield (E.H.), Blacklock (J.B.) and Doppman (J.L.). Mixing studies during intracarotid artery infusions in an in vitro model. J. Neurosurg., 64: 277–283 (1986).
Omojola (M.F.), Fox (A.J.), Auer (R.N.) and Vinuela (F.V.). Hemorrhagic encephalitis produced by selective non-occlusive intracarotid BCNU injection in dogs. J. Neurosurg., 57: 791–796 (1982).
Theron (J.), Villemure (J.G.), Worthington (C.) and Tyler (J.L.): Superselective intracerebral chemotherapy of malignant tumours with BCNU. Neuroradiol., 28: 118–125 (1986).
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© 1987 Martinus Nijhoff Publishers, Dordrecht
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Mikol, F., Moret, J., Mikol, J., Bouchareine, A., Aubin, M.L., Fisch, C. (1987). Cerebral Toxicity Following Supraophthalmic Intracarotid Infusion of BCNU: Study of 4 Malignant Gliomas. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_76
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