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Intraarterial Chemotherapy for Brain Tumors: A Summary of the Ottawa Experience

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Book cover Brain Oncology Biology, diagnosis and therapy

Part of the book series: Developments in Oncology ((DION,volume 52))

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Abstract

Intraarterial administration of chemotherapy results in augmentation of both local peak plasma concentration of the drug and local area under the concentration - times - time curve (AUC) during the drug infusion (1–4). It can be particularly advantageous to administer drugs with a rapid total body clearance intraarterially since if clearance is rapid, the usual AUC will be relatively small, and the local increase in AUC resulting from intraarterial administration will be proportionally quite large (3, 4). For some drugs, intraarterial administration would be expected to result in increased therapeutic efficacy, while for other drugs, there would be relatively little advantage (1–4). Augmentation of local tissue concentrations by intraarterial administration has been documented for some drugs (5–9), but not for others (10).

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Authors and Affiliations

  1. The Ontario Cancer Treatment and Research Foundation Ottawa Regional Cancer Centre and the University of Ottawa Faculty of Health Sciences, Canada

    D. J. Stewart

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  1. D. J. Stewart
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Editors and Affiliations

  1. Department of Neurology, University of Rennes, France

    M. Chatel

  2. Department of Neuropathology, University of Rennes, France

    F. Darcel

  3. Department of Neurosurgery, University of Rennes, France

    J. Pecker

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Stewart, D.J. (1987). Intraarterial Chemotherapy for Brain Tumors: A Summary of the Ottawa Experience. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_72

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  • DOI: https://doi.org/10.1007/978-94-009-3347-7_72

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8003-3

  • Online ISBN: 978-94-009-3347-7

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