Abstract
Studies of survival time of gliomas are usually correlated to histological grading systems. Therapeutic trials were performed under this reference (14). But actuarial survival curves point out a relative disparity in each well defined histologic group (5,15). This data may be related to exceptions without distinctive feature or may bring out other prognostic factors. A lot of these possible factors have been reported: age, functional status, symptomatology, duration of the pre-therapeutic course, C.T. scan aspects (1, 6, 9, 16, 15). To analyse the liability of each factor for prognosis, the usual method requires a successive stratification of the population: two or more subgroups according, for exemple, to age are broken up into other subgroups according to another factor... This method is quickly restricted by the number of cases in each subgroup and can be considered as valid only if each factor is independant of the others. In fact the prognostic is the result of the interactions between them. So it is most interesting to draw up a multivariate analysis taking into accont simultaneously the whole of these factors. A mathematical modeling strategy is required and founded upon their respective role and their connections.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Caudry (M.), Maire (J.-P.), Guerin (J.), Celerier (D.), Demeaux (E.), Banayan (A.), Leman (P.): Gliomes malins sus-tentoriels de l’adulte. Adaptation du traitement aux trois groupes d’une classification clinique : Semaine des hôpitaux. Paris: 59: 453–458 (1983).
Cohadon (F.), Aouad (N.), Rougier (A.), Vital (C.), Rlvel (J.), Dartigues (J.F.): Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors. J. of neuro-oncology 3: 105–111 (1985).
Cox (D.R.): Regression models and lifes-tables: Jr Stat. Soc. (séries B) 34: 187–220 (1972).
Dara (P.), Slater (L.M.), Talreja (D.), Armentrout (S.A.): Long-term survivors of high-grade malignant astrocytomas. Medical and pediatric Oncology: 8: 187–191 (1980).
Jelsma (R.), Bucy (P.C.): Glioblastoma multiforme. Its treatment and some factors effecting survival? Arch. neurol. 20: 161–171 (1971).
Kaplan (E.L.), Meier (P.): Non parametric estimation from incomplete observations. J. Am. Stat. Assoc: 53: 457–481 (1958).
Kernohan (J.W.), Nnabon (R.F.), Svien (H.J.), Adson (A.W.): A simplified classification of the gliomas. Proc. Mayo Clin. 24: 71–75 (1949).
Levin (V.), Hoffman (W.), Heilbron (D.), Norman (D.): Prognostic significance of the pretreatment CT scan on time to progression for patients with malignant gliomas. J. neurosurg. 56, 642–647 (1980).
Nelson (J.S.), Tsudaka (Y.), Schoenfeld (D.), Fulling (K.), Lamarche (J.), Peress (N.): Necrosis as a prognostic criterion in malignant supratentorial, astrocytic gliomas. Cancer: 52: 550–554 (1983).
Ringertz (N.): “Grading” of gliomas. Acta, patho. microbiol. Scand 27, 51–64 (1954).
Rougier (A.), Cohadon (F.), Plgneux (J.), Loiseau (H.): La place de l’irradiation interstitielle dans le traitement des gliomes. Neurochirurgie 30: 125–129 (1984).
Rougier (A.), Plgneux (J.), Rlchaud (P.), Cohadon (F.): La prise en charge diagnostique et thérapeutique des gliomes malins. Neurochirurgie 27: 315–320 (1981).
Salcman (M.): Survival in glioblastoma: historical perspective. Neurosurgery: 7: 435–439 (1980).
Walker (M.), Green (S.), Byar (D.), Alexander (E.), Batzdorf (U.), Brooks (W.), Hunt (W.), Maccarty (C.), Mahaley (S.), Mealey (J.), Owens (G.), Ransohoff (J.), Robertson (J.), Shapiro (W.), Smith (K.), Wilson (C.), Strike (T.): Randomized comparisons of radiotherapy and nitroso ureas for the treatment of malignant glioma after surgery. N. Engl. J. Med.: 303: 1323–1329 (1980).
Weir (B.): The relative significance of factors affecting postoperative survival in astrocytomas grades 3 and 4: J. Neurosurg.: 38, 448–452 (1973).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Rougier, A., Dartigues, J.F., Cohadon, F. (1987). Supra-Tentorial Gliomas: Multivariate Analysis of Prognostic Factors. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_44
Download citation
DOI: https://doi.org/10.1007/978-94-009-3347-7_44
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8003-3
Online ISBN: 978-94-009-3347-7
eBook Packages: Springer Book Archive