Histological Factors in the Prognosis of Malignant Gliomas

  • J. N. Wilden
  • I. Moore
  • J. S. Garfield
Part of the Developments in Oncology book series (DION, volume 52)


The purpose of this study was to explore the hypothesis that duration of survival is related to the degree of de-differentiation or anaplasia in malignant gliomas. Anaplasia was defined as the amount of cellularity, pleomorphism, mitosis, and necrosis. The pathological analysis of these primary brain tumours was aimed at relating the neuropathological findings to biological behavior of the tumour rather than focusing on the neuropathological diagnosis. These two approaches have sometimes been confused in the literature (1), for example, Bailey and Cushing (2) based their histological classification on the resemblance of brain tumours to their embryological counterparts in normal development, whereas as Kernohan and Sayre (3) introduced a system of grading based on the work of Broders (4) relating microscopic appearance to prognosis.

Key words

Gliomas Grading Pronostic Factors 


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • J. N. Wilden
    • 1
  • I. Moore
    • 1
  • J. S. Garfield
    • 1
  1. 1.Departments of Neurosurgery and NeuropathologyWessex Neurological CentreSouthamptonUK

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