Advertisement

Chemically Induced Human Gliomas Occurrence of Brain Gliomas in three Matchbox Manufacturers An occupational risk ?

  • Ph. Bret
  • J. Pialat
  • H. Robert
  • R. Deruty
  • G. Fischer
  • M. Kzaiz
Chapter
  • 38 Downloads
Part of the Developments in Oncology book series (DION, volume 52)

Abstract

Very little is known on the aetiology of brain tumours of the glioma group. In most cases encountered in the daily neurosurgical pratice, no particular factor of risk is advocated in view of the past history of patients. The ability of radiotherapy to induce glioblastoma has been established (4). Induction of intra-cranial tumours by inoculation of viruses is supported by several reports (1) and the possibility of a transmission of brain gliomas among a population of non blood relative patients has been recently emphasized (7). Since the pioneering work of Zimmerman using methylcholanthrene (10), many chemicals have been suspected as brain carcinogenic agents. Nitrosourea is routinely used in laboratory to induce brain tumours in rats (5, 6, 8). Acrylonitrile has also experimentally been identified as a brain carcinogen (3). Other substances are regarded as potentially carcinogenic without specificity for the human brain. The role of chemicals is supported by a recent epidemiologic study (9) showing an increased risk for brain tumours in certain occupations. The 3 patients that are the subject of this report were managed at our institution during the 6 past years for brain glioma and had in common the fact that they had been working in a similar workplace in a matchbox factory. This clinical experience suggests an environmental risk factor, possibly occupational.

Key words

Glioblastoma Brain Glioma Carcinogen Mutagen Occupational cancer 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Copeland (D.D.), Vogel (F.S.), Bigner (D.D.): The induction of intra cranial neoplasms by the inoculation of avian sarcoma virus in perinatal and adult rats. J. Neuropathol. Exp. Neurol., 1975, 34, 340–58.PubMedCrossRefGoogle Scholar
  2. 2.
    INRS: Produits chimiques carcinogènes pour l’homme. Défmitions. Classement. Cahier de notes documentaires n° 123, 1986, 201–03.Google Scholar
  3. 3.
    Maltoni (C.), Ciliberti (A.), Dimaio (V.): Carcinogenicity bioassays on rats in acrylonitrile administered by inhalation and ingestion. Med. Sav., 1977, 68, 401–11.Google Scholar
  4. 4.
    Piatt (J.H.), Blue (J.H.), Schold S.C., Burger (P.C.): Glioblastoma multiforme after radiotherapy from acromegaly. Neurosurgery 1983, 12, 85–9.CrossRefGoogle Scholar
  5. 5.
    Pleven (C.): Survenue élective de glioblastomes lors de la manipulation en laboratoire de recherche des dérivés de la nitrosoguanidine. Press Med., 1984, 37, 13.Google Scholar
  6. 6.
    Schmider (H.H.), Nielsen (S.L.), Schiller (A.L.), Messer (J.): Morphological studies of rat brain tumours induced by N-nitrosomethylurea. J. Neurosurg., 1971, 34, 335–40.CrossRefGoogle Scholar
  7. 7.
    Siqueira (E.B.), Kranzler (L.I.), Schaffer (L.): Occurence of glioblastoma multiforme in three closely related patients. Surg. Neurol. 1985, 24, 387–91.PubMedCrossRefGoogle Scholar
  8. 8.
    Swenberg (J.A.), Koestner (A.), Wechsler (W.): The induction of tumours of the nervous system with intravenous methylnitrosourea. Lab. Invest., 1972, 26, 74–85.PubMedGoogle Scholar
  9. 9.
    Thomas (T.L.), Waxweiler (R.J.): Brain tumors and occupational risk factors. Scand. J. Work Environ. Health 1986, 12, 1–15.Google Scholar
  10. 10.
    Zimmerman (H.M.), Arnold (H.): Experimental brain tumors. 1. Tumors produced with methylcholanthrene. Cancer Res., 1941, 1, 919–38.Google Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • Ph. Bret
    • 1
  • J. Pialat
    • 2
  • H. Robert
  • R. Deruty
    • 3
  • G. Fischer
    • 1
  • M. Kzaiz
    • 1
  1. 1.Service de Neurochirurgie CHôpital Neurologique et Neurochirurgical Pierre WERTHEIMERLyon cedex 3France
  2. 2.Laboratoire d’Anatomie pathologiqueHôpital Neurologique et Neurochirurgical Pierre WERTHEIMERLyon cedex 3France
  3. 3.Service de Neurochirurgie BHôpital Neurologique et Neurochirurgical Pierre WERTHEIMERLyon cedex 3France

Personalised recommendations