Chromosomal Studies in Malignant Gliomas

  • S. H. Bigner
Part of the Developments in Oncology book series (DION, volume 52)


Karyotypic evaluation of lymphomas, leukemias and solid tumors has demonstrated that specific chromosomal abnormalities characterize many of these processes (1). There are now several examples of tumor types in which the chromosomes involved in specific translocations have pointed the way to genes which are important in the evolution of these neoplasms. For example, the 9; 22 translocation of chronic granulocytic leukemia places c-abl in proximity to a breakpoint cluster region on 22q. (2). The protein coded by the rearranged sequence resembles the product of the transforming viral sequence, v-abl. (2). Similary, the 8; 14, 2; 8, and 8; 22 translocations of Burkitt’s lymphoma move the c-myc gene to location near the genes which code for the light and heavy immunoglobulin chains (3).

Key words

Chromosomes Karyotypes Gliomas Brain tumors 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Yunis (J.J.): The Chromosomal Basis of Human Neoplasia. Science 221: 227–235 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    Ben-neriah (Y.), Daley (G.Q.), Mes-Masson (A.M.), Witte (O.N.), Baltimore (D.): The Chronic Myelogenous Leukemia-Specific P210 Protein is the Product of the bcr/abl Hybrid Gene. Science 233: 212–214 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    Croce (C.M.), Tsujmoto (Y.), Erikson (J.), Nowell (P.): Chromosome Translocation and B Cell Neoplasia. Lab Invest 51: 258–267 (1984).PubMedGoogle Scholar
  4. 4.
    Mark (J.): Chromosomal Characteristics of Neurogenic Tumours in Adults. Hereditas 68: 61–100 (1971).PubMedCrossRefGoogle Scholar
  5. 5.
    Mark (J.), Pontén (J.) and Westermark (B.): G-band Analyses of an Established Cell Line of Human Malignant Glioma. Humangenetik 22: 323–326 (1974).PubMedCrossRefGoogle Scholar
  6. 6.
    Mark (J.), Pontén (J.) and Westermark (B.): Cytogenetical Studies with G-band Technique of Established Cell Lines of Human Malignant Gliomas. Hereditas 78: 304–308 (1974).PubMedCrossRefGoogle Scholar
  7. 7.
    Mark (J.), Westermark (B.), Pontén (J.) and Hugoson (R.): Banding Patterns in Human Glioma Cell Lines. Hereditas 87: 243–260 (1977).PubMedCrossRefGoogle Scholar
  8. 8.
    Bigner (S.H.), Mark (J.), Mahaley (M.S.) and Bigner (D.D.): Patterns of the Early, Gross Chromosomal Changes in Malignant Human Gliomas. Hereditas 101: 103–113 (1984).PubMedCrossRefGoogle Scholar
  9. 9.
    Bigner (S.H.), Mark (J.), Bullard (D.E.), Mahaley (M.S.), Jr., and Bigner (D.D.): Chromosomal Evolution in Malignant Human Gliomas Starts With Specific and Usually Numerical Deviations. Cancer Genet Cytogenet 22: 121–135(1986).PubMedCrossRefGoogle Scholar
  10. 10.
    Bigner (S.H.), Mark (J.), Mahaley (M.S.), Jr., Bullard (D.E.), Mulhbair (L.J.) and Bigner (D.D.): Specific Chromosomal Abnormalities Characterize Malignant Human Gliomas. Submitted (1986).Google Scholar
  11. 11.
    Libermann (T.A.), Nusbaum (H.R.), Razon (W.), Kris (R.), Lax (I.), Soreq (H.), Whittle (N.), Waterfield (M.D.), Ullrich (A.) and Schlessinger (J.): Amplification Enhanced Expression, and Possible Rearrangement of the EGF Receptor Gene in Primary Human Brain Tumours of Glial Origin. Nature 313: 144–147 (1985).PubMedCrossRefGoogle Scholar
  12. 12.
    Wong (A.J.), Bigner (S.H.), Bigner (D.D.), Kenzler (K.W.), Hamilton (S.R.) and Vogelstein (B.): Increased Expression of the EGF Receptor Gene in Malignant Gliomas is Invariably Associated With Gene Amplification. Submitted (1986).Google Scholar
  13. 13.
    Cowel (J.K.): Double Minutes and Homogeneously Staining Regions: Gene Amplification in Mammalian Cells, Am Rev. Genet 16: 21–59 (1982).CrossRefGoogle Scholar
  14. 14.
    Yang-Feng (T.L.), Schechter (A.L.), Weinberg (R.A.) and Franke (U.): Oncogene from rat neuro/glioblastomas (human gene symbol NGL is located on the proximal long arm of human chromosome 17 and EGFR is confirmed at 7p13-q11.2. Cytogenet Cell Genet 40: 784 (1985).Google Scholar
  15. 15.
    Bigner (S.H.), Wong (A.J.), Mark (J.), Muhlbaier (L.H.), Klnzler (K.W.), Vogelstein (B.) and Bigner (D.D.): Relationship Between Gene Amplification and Chromosomal Deviations in Malignant Human Gliomas. Submitted (1986).Google Scholar
  16. 16.
    Bell (C.), Harsh (I.V.), (G.), Rosenblum (M.), Meltzer (P.) and Trent (J.): Numeric and Structural Alterations of Chromosome 7 in Human Brain Tumors: Correlation With Expression of Epidermal Growth Factor Receptor (EGFR). Proc. AACR 27: 37 (1986).Google Scholar
  17. 17.
    Henn (W.), Blin (N.), Zang (K.D.): Polysomy of Chromosome 7 is Correlated With Overexpression of the erbB Oncogene in Human Glioblastoma Cell Lines. Human Genet 74: 104–106 (1986).CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • S. H. Bigner
    • 1
  1. 1.Department of PathologyDuke University Medical CenterDurhamUSA

Personalised recommendations