Can Polyamines act as Positron Emitters in Cerebral Oncology? Preliminary results obtained in nude mice bearing human glioblastoma xenografts
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The polyamines, such as putrescine (PUT), spermidine (SPD) and spermine (SPM) are saturated organic compounds which are present in abnormally high concentration in malignant brain tumours (1, 2,3). In addition, the levels of PUT and SPD in the tumour are, statistically speaking, proportional to the histological grade of the tumour (2, 4). Furthermore, Marton et al. (5, 6) demonstrated that the presence of a brain tumour was associated with a significant increase in the concentration of PUT in the CSF; this type of analysis has been found to be very useful in the management of medulloblastoma (7, 8). In a similar vein, we have observed that the levels of SPD and SPM measured in the red blood cells were significantly elevated in patients afflicted with malignant supratentorial tumours (4). The determination of RBC polyamine levels now appears to have clinical applications, not only for monitoring (9, 10) but also during the post-operative treatment of patients with malignant gliomas (11).
Key wordsPolyamines Gliomas Positron Nude mice Xenografts
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