Neuropathology and Regional Imaging of Microcirculation, Tissue pH, Metabolites and Necroses in Cerebral RG2 and F98 Anaplastic Rat Glioma Transplantation Tumors

  • W. Wechsler
  • U. Teske
  • G. Reifenberger
  • M. Deckert
  • R. J. Seitz
  • G. Mies
  • W. Paschen
  • K.-A. Hossmann
Part of the Developments in Oncology book series (DION, volume 52)


Malignant human gliomas corresponding to grade III and IV are anaplastic ependymomas, anaplastic astrocytomas, anaplastic oligodendrogliomas, anaplastic mixed gliomas and the glioblastoma group (WHO classification, 43). These high-grade gliomas are characterized by an increased rate of cell proliferation and by special regressive changes, such as mucoid and fatty degeneration, cyst formation and in particular by tumor necrobiosis and/or necrosis (33, 46). Size and kind of necroses, however, vary with regard to tumor type and tumor grade. Whereas anaplastic gliomas contain by definition multiple and sometimes abundant necrotic foci, in glioblastomas microscopic necroses of the pseudo palisading type occur as well as macroscopically visible large areas of multicentric necroses.

Key words

RG2 and F98 rat glioma clones monolayer cultures spheroid cultures cerebral transplantation tumors neuropathology immunohistochemistry tumor vascularization microcirculation metabolism tissue pH tumor necroses 


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • W. Wechsler
    • 1
  • U. Teske
    • 1
  • G. Reifenberger
    • 1
  • M. Deckert
    • 1
  • R. J. Seitz
    • 2
  • G. Mies
    • 3
  • W. Paschen
    • 3
  • K.-A. Hossmann
    • 3
  1. 1.Department of NeuropathologyGermany
  2. 2.Department of NeurologyUniversity of DüsseldorfGermany
  3. 3.Department of Experimental NeurologyMax-Planck-Institut für Neurologische ForschungCologneGermany

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