Metabolic Studies of Brain Tumours by PET
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Positron Emission Tomography (PET) provides a relatively non-invasive means of determining the metabolic activity in vivo of normal or abnormal areas of human brain. Suitable positron emitting isotopes include 15O, 11C, 18F, and 82Rb. Many naturally occurring organic molecules can be tagged with these agents and their regional distribution in the brain mapped out in tomographic slices. PET can be used simply as an imaging device, but it has a far greater potential as a means of studying regional cerebral blood flow, oxygen and glucose metabolism, and the transport of substrates across the blood-brain barrier (BBB). The application of PET to study metabolism using tracer kinetic modelling in these areas will be described.
Key wordsMetabolism of Brain Tumours PET Positron emission tomography
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