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Metabolic Studies of Brain Tumours by PET

  • D. G. T. Thomas
  • D. J. Brooks
  • T. Jones
Chapter
  • 36 Downloads
Part of the Developments in Oncology book series (DION, volume 52)

Abstract

Positron Emission Tomography (PET) provides a relatively non-invasive means of determining the metabolic activity in vivo of normal or abnormal areas of human brain. Suitable positron emitting isotopes include 15O, 11C, 18F, and 82Rb. Many naturally occurring organic molecules can be tagged with these agents and their regional distribution in the brain mapped out in tomographic slices. PET can be used simply as an imaging device, but it has a far greater potential as a means of studying regional cerebral blood flow, oxygen and glucose metabolism, and the transport of substrates across the blood-brain barrier (BBB). The application of PET to study metabolism using tracer kinetic modelling in these areas will be described.

Key words

Metabolism of Brain Tumours PET Positron emission tomography 

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References

  1. 1.
    Frackowiak (R.S.J.), Lenzi (G.L.), Jones (T.), Heather (J.D.): Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure and normal values. J. Comput Assist. Tomogr. 1980, 4: 727–736.PubMedCrossRefGoogle Scholar
  2. 2.
    Ito (M.), Lammertsma (A.A.), Wise (R.J.S.), Bernardi (S.), Frackowiak (R.S.J.), Heather (J.D.), McKenzie (C.G.), Thomas (D.G.T.), Jones (T.): Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using 15O and positron emission tomography: analytical techniques and preliminary results. Neuroradiology 1982, 23: 63–74.PubMedCrossRefGoogle Scholar
  3. 3.
    Beaney (R.P.), Brooks (D.J.), Leenders (K.L.), Thomas (D.G.T.), Jones (T.) and Halnan (K.E.): Blood flow and oxygen utilisation in the contralateral cerebral cortex of patients with untreated intracranial tumours as studied by positron emission tomography, with observations on the effect of decompressive surgery. Neurol. Neurosurg. Psychiat. 1985, 48: 310–319.CrossRefGoogle Scholar
  4. 4.
    Rhodes (C.G.), Wise (R.J.S.), Gibbs (J.M.), Frackowiak (R.S.J.), Hatazawa (J.), Palmer (A.J.), Thomas (D.G.T.) and Jones (T.): In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas. Ann. Neurol. 1983, 14: 614–626.PubMedCrossRefGoogle Scholar
  5. 5.
    Brooks (D.J.), Beaney (R.P.), Lammertsma (A.A.), Leenders (K.L.), Horlock (P.L.), Kensett (M.J.), Marshall (J.), Thomas (D.G.T.) and Jones (T.): Quantitative measurement of blood-brain barrier permeability using rubidium-82 and positron emission tomography. Cereb. Blood Flow Metab. 1984, 4: 535–545.CrossRefGoogle Scholar
  6. 6.
    Wise (R. J. S.), Thomas (D. G. T.), Lammertsma (A.A.) and Rhodes (C.G.): PET scanning of human brain tumours. Prog. exp. Tumor Res., 1984, 27: 154–169.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • D. G. T. Thomas
    • 1
  • D. J. Brooks
    • 2
  • T. Jones
    • 2
  1. 1.Department of Neurological SurgeryThe National Hospital, Institute of NeurologyQueen Square, LondonUK
  2. 2.MRC Cyclotron UnitHammersmith HospitalLondonUK

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