Trials of Hormonal Manipulation of Meningiomas in vivo and in vitro

  • T. M. Markwalder
  • E. Waelti
Part of the Developments in Oncology book series (DION, volume 52)


Clinical and epidemiological features (1–4) and the presence of remarkably high titers of a nonestrogen regulated (5–9) high-affinity / limited capacity progesterone receptor (PR) in over 70% of cytosols (10–15, 5–7, 16, 9, 17) are in favour of a sex hormone dependency of tumor growth in menillgiomas. We have studied the influence of sexual steroid hormones on growth of primary meningioma cells in monolayer tissue culture and in vivo because adjuvant hormonotherapy would represent, if effective, a desirable therapeutic measure if surgical resection is impossible or only partially practicable because of the tumor location or advanced age.

Key words

Progesterone Receptors Meningioma Growth Modulation Medroxyprogesterone acetate 


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • T. M. Markwalder
    • 1
  • E. Waelti
    • 1
  1. 1.Department of Neurosurgery and Institute of PathologyUniversity of BernBernSwitzerland

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