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Preliminary Assessment of the Correlation between Clinicopathological Features of Intracranial Tumours and the Amount of Extractable Angiogenic Activity: High and Low Mr factors

  • J. Vafidis
  • J. E. Meats
  • H. Reid
  • R. H. Lye
  • J. B. Weiss
Chapter
Part of the Developments in Oncology book series (DION, volume 52)

Abstract

An adequate blood supply is essential to the continued growth of an intracranial neoplasm (1). Tumour factors capable of inducing host endothelial cells to proliferate, form capillaries and so migrate towards a neoplasm have been described (2,3). These factors are broadly grouped into high (approx. 20,000) and low (300–600) molecular mass (Mr) categories (2, 4, 5, 6, 7). Angiogenic activity has been demonstrated in cell cultures of meningiomas (7).

Key words

Angiogenesis Angiography Brain tumour Computed tomography Endothelial cell Meningiomas Neoplasm 

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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • J. Vafidis
    • 1
  • J. E. Meats
    • 1
  • H. Reid
    • 1
  • R. H. Lye
    • 1
  • J. B. Weiss
    • 1
  1. 1.Departments of Neurosurgery, Neuropathology and Medical BiochemistryUniversity of ManchesterUK

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