Preliminary Assessment of the Correlation between Clinicopathological Features of Intracranial Tumours and the Amount of Extractable Angiogenic Activity: High and Low Mr factors
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An adequate blood supply is essential to the continued growth of an intracranial neoplasm (1). Tumour factors capable of inducing host endothelial cells to proliferate, form capillaries and so migrate towards a neoplasm have been described (2,3). These factors are broadly grouped into high (approx. 20,000) and low (300–600) molecular mass (Mr) categories (2, 4, 5, 6, 7). Angiogenic activity has been demonstrated in cell cultures of meningiomas (7).
Key wordsAngiogenesis Angiography Brain tumour Computed tomography Endothelial cell Meningiomas Neoplasm
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