Abstract
An adequate blood supply is essential to the continued growth of an intracranial neoplasm (1). Tumour factors capable of inducing host endothelial cells to proliferate, form capillaries and so migrate towards a neoplasm have been described (2,3). These factors are broadly grouped into high (approx. 20,000) and low (300–600) molecular mass (Mr) categories (2, 4, 5, 6, 7). Angiogenic activity has been demonstrated in cell cultures of meningiomas (7).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Folkman (J.), Taylor (S.), Spillberg (C.): The role of heparin in angiogenesis. in Ciba foundation Symposium 100: Development of the vascular system (Pitman 1983), pp. 132–149.
Folkman (J.), Merler (E.), Abernathy (C.), Williams (G.): Isolation of a tumour factor responsible for angiogenesis. J. Exp. Med. 275–278, 1971.
Auerbach (R.): Angiogenesis-inducing factors: a review. Lymphokines 4: 69–88, 1981.
Shing (Y.), Folkman (J.), Sullivan (R.), Butterfield (C.), Murray (J.), Klagsburn (M.): Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223: 1295–1298, 1984.
Weiss (J.B.), Brown (R.A.), Kumar (S.), Phillips (P.): Angiogenic factor isolated from tumours: a potential low molecular-weight compound. Brit. J. Cancer 40; 493–496, 1979.
Mcauslan (B.R.), Hoffman (H.): Endothelium stimulating factor from Walker carcinoma cells. Relation to tumor angiogenic factor. Expl. Cell Res. 119: 181–190, 1979.
Fenselau (A.), Watt (S.), Mello (R.J.): Tumour angiogenic factor. Purification from the Walker 256 rat tumour. J. Biol. Chem. 256: 9605–9611, 1981.
Warren (B.A.): Tumor angiogenesis. in Peterson H-I (ed.). Tumor Blood Circulation: angiogenesis, vascular morphology and blood flow of experimental and human tumors (CRC Press Inc. 1979), pp. 49–75.
Brem (S.), Cotran (R.), Folkman (J.): Tumor Angiogenesis. A Quantitative Method for Histologic Grading. J. National Cancer Institute 48: 347–354, 1972.
Lye (R.H.), Elstow (S.F.), Weiss (J.B.): Neovascularisation of intracranial tumours. in Walker M.D., Thomas D.G.T. (eds). Biology of Brain Tumour (Martinus Nijhoff Publishers) 1986, pp. 61–66 (in press).
Gado (M.H.), Phelps (M.E.), Coleman (R.F.): An extravaseular component of contrast enhancement in cranial computed tomography. Part II: Contrast enhancement and the blood-tissue barrier. Radiology 117: 595–597, 1975.
Dubois (P.J.), Drayer (B.P.), Heinz (E.R.), Osborne (D.), Roberts (L.), Sage (M.): Rapid serial cranial computed tomography for tumor diagnosis. Neuroradiology 21: 79–86, 1981.
Vassilouthis (J.), Ambrose (J.): Computerized tomography scanning appearances of intracranial meningiomas. J. Neurosurg. 50: 320–327, 1979.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Vafidis, J., Meats, J.E., Reid, H., Lye, R.H., Weiss, J.B. (1987). Preliminary Assessment of the Correlation between Clinicopathological Features of Intracranial Tumours and the Amount of Extractable Angiogenic Activity: High and Low Mr factors. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_26
Download citation
DOI: https://doi.org/10.1007/978-94-009-3347-7_26
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8003-3
Online ISBN: 978-94-009-3347-7
eBook Packages: Springer Book Archive