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The Selective Release of Polypeptides from Human Glioma Cell Cultures and their Modification by Dexamethasone

  • D. E. Bateman
  • J. R. McDermott
  • D. Hughes
  • J. A. Edwardson
Chapter
  • 37 Downloads
Part of the Developments in Oncology book series (DION, volume 52)

Abstract

Human and animal glioma cell cultures release a number of products (1, 2) some of which have biological activity, eg endothelial proliferation factor (3). In the case of animal glioma cultures the release of these products is modified by steroids such as hydrocortisone (4).

Key words

Polypeptides Glioma Culture Dexamethasone 

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References

  1. 1.
    McKeever (P.E.), Quindlen (E.), Banks (M.A.), Williams (V.), Kornblith (P.L.), La Verson (S.), Greenwood (M.A.), Smith (B.): Biosynthesised products of cultured neuroglial cells; 1 Selective release of proteins by cells from human astrocytomas. Neurology 1981, 31, 1445–1452.PubMedGoogle Scholar
  2. 2.
    Arenander (A.T.), Vellis (J. de): Glial released proteins: 111 Influence on neuronal morphological differentiation. Brain Res 1981, 224, 117–127.PubMedCrossRefGoogle Scholar
  3. 3.
    Suddith (R.L.), Kelly (P.J.), Hutchison (H.T.), Murray (E.A.), Haber (B.): In vitro demonstration of an endothelial proliferative factor produced by neural cell lines. Science 1975, 190, 682–684.PubMedCrossRefGoogle Scholar
  4. 4.
    Arenander (A.T.), Vellis (J. de): Glial released proteins in clonal cultures and their modulation by hydrocortisone. Brain Res 1980, 200, 401–409.PubMedCrossRefGoogle Scholar
  5. 5.
    Molnar (P.), Blasberg (R.G.), Horowitz (M.), Smith (B.), Fenstermacher (J.): Regional blood to tissue transport in RT - 9 brain tumours. J. Neurosurg. 1983a, 58, 874–884.PubMedCrossRefGoogle Scholar
  6. 6.
    Freshney (R.I.): Tissue culture of glioma of the brain in Brain Tumors eds D.G.T. Thomas and D.I. Graham Butterworths 1980, 42–47.Google Scholar
  7. 7.
    Laemmli (U.K.): Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 1970, 227, 680–685.PubMedCrossRefGoogle Scholar
  8. 8.
    Shitara (N.), Mckeever (P.E.), Smith (B.H.), Pleasants (R.E.), Banks (M.A.), Kornblith (P.L.): Products of neuroglial cells III, J. Neurochem. 1982, 39, 948–953.PubMedCrossRefGoogle Scholar
  9. 9.
    Norrgren (G.), Ebendal (T.), Belew (M.), Jacobson (C.O.), Porto (J.): Release of nerve growth factor by human glial cells in culture. Exp. cell Res. 1980, 130, 31–39.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • D. E. Bateman
    • 1
  • J. R. McDermott
    • 2
  • D. Hughes
    • 2
  • J. A. Edwardson
    • 2
  1. 1.Southampton General HospitalWessex Neurological CentreUK
  2. 2.MRC Neuroendocrinology UnitNewcastle upon TyneUK

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