Abstract
Although they were first detected at the end of the 18th century by the famous chemist A. Vauquelin (1), who, among other achievements, first formulated the concept of the amino acid, the true significance of polyamines did not become apparent until the second half of the 20th century. For a long time they were erroneously considered to be “simple” end products of degradation, a view which is reflected in the names which were attached to them (putrescine, cadaverine, spermidine, spermine), before their finely regulated metabolism and their relationship with the cell cycle came to be studied (2).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Vauquelin (A.): Expériences sur le sperme humain. Ann. Chim., 9, 64–80 (1791).
Heby (O.): Roles of polyamines in the control of cell proliferation and differenciation, Differentiation, 19, 1–20 (1981).
Russel (D.H.): Increased polyamines concentrations in the urine of human cancer patients, Nature, 233, 144–145 (1971).
Scalabrino (G.), Ferioli (M.E.): Polyamines in mammalian tumors. Adv. in Cancer Res., Vol. 35 (Part I), Vol. 36 (Part II), Academic Press, Inc. (1982).
Marton (L.J.), Heby (O.), Wilson (C.B.): Increased polyamine concentrations in the CSF of patients with brain tumors. Int. J. Cancer, 14, 731–735 (1974).
Marton (L.J.), Edwards (M.S.), Levin (V.A.), Lubich (W.P.), Wilson (C.B.): The relationship of polyamines in the CSF to the presence of central nervous system tumors, Cancer Res., 39, 993–997 (1979).
Marton (L.J.), Edwards (M.S.), Levin (V.A.), Lubich (W.P.), Wilson (C.B.): CSF polyamines: a new and important means of monitoring patients with medulloblastoma. Cancer, 47, 757–760 (1981).
Moulinoux (J.-PH.), Quemener (V.), Quash (G.A.): In vitro studies on the entry of polyamines into normal red blood cells, Biochimie, 66, 385–393, (1984).
Moulinoux (J.-PH.), Quemener (V.), Larzul (J.J.), Roch (A.M.), Toujas (L.), Quash (G.A.): Red blood cell polyamines in mice bearing the Lewis lung carcinoma (3LL) and in patients with bronchopulmonary cancers, Int. J. Cancer, 34, 277–281 (1984).
Moulinoux (J.-PH.), Delamaire (D.), Beau (B.), Quemener (V.), Brissot (P.), Le Calve (M.), Deugnier (Y.), Chambon (Y.), Bourel (M.): Diagnosis value of erythrocyte polyamines and histaminemia in malignant hepatic tumors and in liver cirrhosis, Clin. Chim. Acta, 145, 77–87 (1985).
Quemener (V.), Le Gall (E.), Edan (C.), Moulinoux (J.-PH.): Red blood cell polyamine levels in children with acute leukemia: their clinical interest in desease staging and monitoring of therapy efficiency. Cancer J., 1 (4), 174–180 (1986).
Moulinoux (J.-PH.), Quemener (V.), Chatel (M.), Darcel (F.): Polyamines in human brain tumors: a correlative study between tumor, CSF and red blood cell free polyamines levels, J. Neuro-Oncology, 2, 153–158 (1984).
Moulinoux (J.-PH.), Quemener (V.), Hercouet (H.), Darcel (F.), Chatel (M.): Red blood cell polyamines in malignant glioma patients. Spermidine and spermine blood levels and tumour evolution, Biology of Brain Tumour, MD Walker and DGT Thomas (eds), Martinus Nijhoff Publishers, Boston, 67–74 (1986).
Chatel (M.), Darcel (F.), Quemener (V.), Moulinoux (J.-PH.): Red blood cell polyamines as biochemical markers of supratentorial malignant gliomas. J. Anticancer Res., in press (1986).
Pecker (J.), Chatel (M.), Moulinoux (J.-PH.), Darcel (F.): Intérêt du dosage des polyamines dans la surveillance évolutive des tumeurs neuro-épithéliales de Fencéphale, Bull. Acad. Nat. Méd., 168, 626–634 (1984).
Scalabrino (G.), Modena (D.), Ferioli (M.E.), Puerari (M.): Degrees of malignancy in human primary CNS tumors: ODC levels as better indicators than adenosyl-methionine decarboxylase levels, JNCI, 68, 751–754 (1982).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishers, Dordrecht
About this chapter
Cite this chapter
Moulinoux, J.P., Quemener, V., Darcel, F., Faivre, J., Chatel, M. (1987). Red Blood cell Polyamines in the Long Term Follow-up of Malignant Gliomas. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_24
Download citation
DOI: https://doi.org/10.1007/978-94-009-3347-7_24
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8003-3
Online ISBN: 978-94-009-3347-7
eBook Packages: Springer Book Archive