Oncogenes, Growth Factors and the Pathogenesis of Human Glioma: The 1986 Engelhardt Lecture

  • B. Westermark
  • M. Nistér
  • C. H. Heldin
Part of the Developments in Oncology book series (DION, volume 52)


Cancer is generally believed to evolve through a multihit mechanism involving several genetic lesions. Those genes, whose expression convert cells to a neoplastic phenotype, are collectively called oncogenes. In recent years, it has become evident that the oncogenes do not constitute a novel genetic material in the transformed cell but represent altered versions of normal cellular genes (proto-oncogenes). The latter can be activated to transforming oncogenes through specific genetic mechanisms, summarized in fig. 1.

Key words

Oncogenes Growth factors Glioma 


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • B. Westermark
  • M. Nistér
  • C. H. Heldin

There are no affiliations available

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