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Modulation of Class I and Class II Major Histocompatibility Complex Antigens in Gliomas

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Brain Oncology Biology, diagnosis and therapy

Part of the book series: Developments in Oncology ((DION,volume 52))

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Abstract

The concept of major histocompatibility complex (MHC) proposed by Gorer in 1937 (1) has been intensively developped in the last twenty years. Denoted H-2 in mice and HLA (Human Lymphocyte Locus A) in humans, it is a well defined locus on chromosome 17 in mice and on the short arm of chromosome 6 in humans. This system and its functions are present in all vertebrates (2). Following the physicochemical characteristics of proteins expressed by these genes, 3 families of MHC products have been defined and denoted class I, II and III (3). The first part of this chapter attempts to describe the main concepts associated with class I and II MHC antigens, especially their specific biological functions. We do not attempt to present class III products which correspond to proteins implicated in the complement system and do not seem to play a major role in the immune response directed against cancer.

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  1. Neurosurgical Service, University Hospital, CH 1011, Lausanne, Switzerland

    P. Zuber & N. de Tribolet

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  1. P. Zuber
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  1. Department of Neurology, University of Rennes, France

    M. Chatel

  2. Department of Neuropathology, University of Rennes, France

    F. Darcel

  3. Department of Neurosurgery, University of Rennes, France

    J. Pecker

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© 1987 Martinus Nijhoff Publishers, Dordrecht

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Zuber, P., de Tribolet, N. (1987). Modulation of Class I and Class II Major Histocompatibility Complex Antigens in Gliomas. In: Chatel, M., Darcel, F., Pecker, J. (eds) Brain Oncology Biology, diagnosis and therapy. Developments in Oncology, vol 52. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3347-7_19

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  • DOI: https://doi.org/10.1007/978-94-009-3347-7_19

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