Correlation of in situ cell Kinetics and Degree of Anaplasia in Human Brain Tumors: Identification of S-phase cells with anti-BUdR Antibodies

  • S. J. De Armond
  • T. Nagashima
  • K. G. Cho
  • J. A. Murovic
  • R. L. Davis
  • T. Hoshino
Part of the Developments in Oncology book series (DION, volume 52)


The goal of the neuropathological examination of a cerebral neoplasm is to obtain an accurate measure of its proliferative potential. The underlying assumption made by those who must treat patients is that there is a direct correlation between the histological characteristics of a brain tumor and its prognosis and its response to treatment. However, experience has shown that there is often a considerable variation in the clinical behavior and rate of proliferation of neoplasms with the same histological characteristics.

Key words

Cell Kinetics Grading BUdR Antilodies 


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Copyright information

© Martinus Nijhoff Publishers, Dordrecht 1987

Authors and Affiliations

  • S. J. De Armond
    • 1
  • T. Nagashima
    • 2
  • K. G. Cho
    • 2
  • J. A. Murovic
    • 2
  • R. L. Davis
    • 2
  • T. Hoshino
    • 2
  1. 1.The Department of Pathology (Neuropathology Unit), Brain Tumor Research CenterSchool of Medicine, University of CaliforniaSan Francisco 94/43USA
  2. 2.The Department of Neurological Surgery, Brain Tumor Research CenterSchool of Medicine, University of CaliforniaSan Francisco 94/43USA

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